Determination of the basicity of Mannich ketones by capillary electrophoresis

Zs Dobos, T. Lóránd, F. Hollósy, B. Hallgas, D. Eros, Gy Mészáros, G. Kéri, M. Idei

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Capillary electrophoretic (CE) method to characterise Mannich ketones (MKs) containing morpholine moiety was developed. Basicity (pKa,exp) of the MKs was characterised by measured data derived from the electrophoretic mobility values obtained in the CE separation. The MKs were found to be weaker bases than the parent morpholine molecule itself and the experimentally determined basicity values proved to be dependent on the chemical structure of the MKs. Since the basicity of the MKs has an influence on their reactivity and biological activity it seems to be useful to determine experimentally the pKa,exp values of the newly synthesised compounds to support rational drug design or screening of the molecule libraries.

Original languageEnglish
Pages (from-to)179-183
Number of pages5
JournalJournal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Volume799
Issue number1
DOIs
Publication statusPublished - Jan 5 2004

Fingerprint

Capillary electrophoresis
Capillary Electrophoresis
Alkalinity
Ketones
Electrophoretic mobility
Preclinical Drug Evaluations
Molecules
Drug Design
Bioactivity
Libraries
Screening
Pharmaceutical Preparations

Keywords

  • Basicity
  • Mannich ketones

ASJC Scopus subject areas

  • Biochemistry

Cite this

Determination of the basicity of Mannich ketones by capillary electrophoresis. / Dobos, Zs; Lóránd, T.; Hollósy, F.; Hallgas, B.; Eros, D.; Mészáros, Gy; Kéri, G.; Idei, M.

In: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, Vol. 799, No. 1, 05.01.2004, p. 179-183.

Research output: Contribution to journalArticle

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