Determination of the aminoterminal peptide of procollagen type III and laminin P1 in serum of patients with chronic liver disease.

M. Kárteszi, L. Szalay, A. Cornides, K. Dávid, J. Fehér

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Abstract

Serum concentration of the aminoterminal peptide of procollagen type III (P III P) and that of the high-molecular-weight glycoprotein laminin P1 (LP1) were determined by a specific radioimmunoassay (RIA) in patients with different chronic liver diseases. Besides the routine laboratory tests, histological verification of the liver samples obtained by needle biopsy and a complex hepatitis B virus marker analysis by RIA (Biomedica-Sorin), or ELISA (Behringwerke, Marburg, FRG) kits were carried out in order to set up the correct clinical diagnosis. In normal controls, the P III P and LP1 concentrations were 7.8 +/- 1.1 ng/ml (n = 10) and 0.08 +/- 0.1 units/ml (n = 7), respectively. Patients with fatty liver (n = 25) showed a significant elevation in P III P concentration (18.6 +/- 2.7 ng/ml). Such an elevation was not unequivocally demonstrated before. In this group of patients LP1 level was also increased (1.4 +/- 0.2 units/ml, n = 10). In liver cirrhosis (n = 51) both P III P and LP1 concentrations were found to be consistently elevated.

Original languageEnglish
Pages (from-to)277-286
Number of pages10
JournalActa Medica Hungarica
Volume45
Issue number3-4
Publication statusPublished - 1988

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Collagen Type III
Liver Diseases
Chronic Disease
Peptides
Serum
Radioimmunoassay
Needle Biopsy
Fatty Liver
Hepatitis B virus
Liver Cirrhosis
Glycoproteins
Molecular Weight
Enzyme-Linked Immunosorbent Assay
procollagen Type III-N-terminal peptide
laminin P1
Liver

ASJC Scopus subject areas

  • Medicine(all)

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Determination of the aminoterminal peptide of procollagen type III and laminin P1 in serum of patients with chronic liver disease. / Kárteszi, M.; Szalay, L.; Cornides, A.; Dávid, K.; Fehér, J.

In: Acta Medica Hungarica, Vol. 45, No. 3-4, 1988, p. 277-286.

Research output: Contribution to journalArticle

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AU - Fehér, J.

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