Determination of Pt Concentration in Cervical Tumor Tissues Using Energy-Dispersive X-Ray-Fluorescence (EDXRF) Method

K. L. Szluha, I. Uzonyi, J. Bacso, L. Lampe, I. Czifra, M. Peter, C. Villena, W. Schmidt

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Biopsy samples taken from cervical cancer patients after intraarterial and intravenous administration of Cisplatin were analyzed by the energy-dispersive x-ray fluorescence (EDXRF) method. Distribution of platinum (Pt) within the tumor and in its proximity was studied. Pt concentration seems to depend on the mode of administration. Intraarterial administration of Cisplatin resulted in seven times higher Pt concentration in the tumor tissue than the intravenous administration. EDXRF proved to be a useful tool for the determination of Pt in biopsy tissues.

Original languageEnglish
Pages (from-to)238-244
Number of pages7
JournalMicrochemical Journal
Issue number1-2
Publication statusPublished - Feb 1 1995


ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

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