Determination of partition coefficients of pyrido[1,2-a]pyrimidin-4-one derivatives by traditional shake, thin-layer chromatographic and gas-liquid chromatographic methods

O. Papp, K. Valkó, Gy Szász, I. Hermecz, J. Vámos, K. Hankó, Zs Ignáth-halász

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In the investigation of quantitative structure-activity relationships, one of the most important linear free-energy related parameters is the logarithmic value of water-1-octanol partition coefficients (log P) and π values derived from that. Partition coefficients of eighteen pyrido[1,2-a]pyrimidin-4-one compounds were measured for the water-1-octanol solvent system by spectrophotometric methods. RM values and corrected ΔI values of the compounds were also determined by thin-layer chromatographic and gas-liquid chromatographic methods, respectively. The excellent correlations found between these log P, RM and corrected ΔI values prove that liquid-liquid partition data can be obtained not only by thin-layer chromatography or high-performance liquid chromatography but also by gas-liquid chromatography.

Original languageEnglish
Pages (from-to)67-75
Number of pages9
JournalJournal of Chromatography A
Volume252
Issue numberC
DOIs
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Determination of partition coefficients of pyrido[1,2-a]pyrimidin-4-one derivatives by traditional shake, thin-layer chromatographic and gas-liquid chromatographic methods'. Together they form a unique fingerprint.

  • Cite this