Determination of partition coefficients of pyrido[1,2-a]pyrimidin-4-one derivatives by traditional shake, thin-layer chromatographic and gas-liquid chromatographic methods

O. Papp, K. Valkó, G. Szász, I. Hermecz, J. Vámos, K. Hankó, Zs Ignáth-halász

Research output: Contribution to journalArticle

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Abstract

In the investigation of quantitative structure-activity relationships, one of the most important linear free-energy related parameters is the logarithmic value of water-1-octanol partition coefficients (log P) and π values derived from that. Partition coefficients of eighteen pyrido[1,2-a]pyrimidin-4-one compounds were measured for the water-1-octanol solvent system by spectrophotometric methods. RM values and corrected ΔI values of the compounds were also determined by thin-layer chromatographic and gas-liquid chromatographic methods, respectively. The excellent correlations found between these log P, RM and corrected ΔI values prove that liquid-liquid partition data can be obtained not only by thin-layer chromatography or high-performance liquid chromatography but also by gas-liquid chromatography.

Original languageEnglish
Pages (from-to)67-75
Number of pages9
JournalJournal of Chromatography A
Volume252
Issue numberC
DOIs
Publication statusPublished - 1982

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1-Octanol
Gases
Derivatives
Quantitative Structure-Activity Relationship
Water
Liquids
Thin Layer Chromatography
Gas Chromatography
Thin layer chromatography
High Pressure Liquid Chromatography
Liquid chromatography
High performance liquid chromatography
Gas chromatography
Free energy

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Determination of partition coefficients of pyrido[1,2-a]pyrimidin-4-one derivatives by traditional shake, thin-layer chromatographic and gas-liquid chromatographic methods. / Papp, O.; Valkó, K.; Szász, G.; Hermecz, I.; Vámos, J.; Hankó, K.; Ignáth-halász, Zs.

In: Journal of Chromatography A, Vol. 252, No. C, 1982, p. 67-75.

Research output: Contribution to journalArticle

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AU - Vámos, J.

AU - Hankó, K.

AU - Ignáth-halász, Zs

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