Determination of Oxalate Excretion in Spot Urines of Healthy Children by Ion Chromatography

C. Von Schnakenburg, D. J. Byrd, K. Latta, G. Reusz, Dorothee Graf, J. Brodehl

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Evidence for the suitability of spot urines for selective screening in children was obtained by comparing the 24-hour urinary oxalate excretion with the ratio of urinary oxalate to creatinine [mmol/mol] in spontaneously voided urine samples. Spot urines of 169 healthy children aged 1 day to 13 years were analysed in order to establish reference values for the urinary oxalate/creatinine ratio in relation to age and body surface area. Oxalate was measured by automated ion chromatography. Results showed an inverse relationship between the oxalate/creatinine ratio and age. The highest ratios, 131 ±57 mmol/mol (mean ± 2 SD), were found in infants. At age two years, the ratio was 84 ± 55, at age five years 56 ± 35, and for children older than ten years 42 ± 31. This finding can be explained by the gain of muscle mass and hence increased creatinine production with increasing age. Data for the urinary oxalate/creatinine ratio are presented according to body surface area for the assessment of children with abnormal growth. In 19 urine samples from nine patients with primary hyperoxaluria, the oxalate/creatinine ratio greatly exceeded (286—2022 mmol/mol) the above reference ranges. We therefore propose the determination of the oxalate/creatinine ratio in spot urines for the selective screening for hyperoxaluria in children with nephrocalcinosis or urolithiasis.

Original languageEnglish
Pages (from-to)27-30
Number of pages4
JournalClinical Chemistry and Laboratory Medicine
Volume32
Issue number1
DOIs
Publication statusPublished - 1994

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Ion chromatography
Oxalates
Chromatography
Creatinine
Urine
Ions
Body Surface Area
Screening
Reference Values
Primary Hyperoxaluria
Hyperoxaluria
Nephrocalcinosis
Urolithiasis
Muscle
Muscles
Growth

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Determination of Oxalate Excretion in Spot Urines of Healthy Children by Ion Chromatography. / Von Schnakenburg, C.; Byrd, D. J.; Latta, K.; Reusz, G.; Graf, Dorothee; Brodehl, J.

In: Clinical Chemistry and Laboratory Medicine, Vol. 32, No. 1, 1994, p. 27-30.

Research output: Contribution to journalArticle

Von Schnakenburg, C. ; Byrd, D. J. ; Latta, K. ; Reusz, G. ; Graf, Dorothee ; Brodehl, J. / Determination of Oxalate Excretion in Spot Urines of Healthy Children by Ion Chromatography. In: Clinical Chemistry and Laboratory Medicine. 1994 ; Vol. 32, No. 1. pp. 27-30.
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