Determination of N9/N7-isomer ratio of alkyl (guaninyl)acetates by electrospray ionization tandem mass spectrometry

Györgyi Ferenc, Zoltán Kele, Lajos Kovács

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

N9- and N7-Substituted (guaninyl)acetic esters were studied by electrospray ionization tandem mass spectrometry (ESI-MS/MS) in order to determine their ratio in alkylation reactions. The loss of ammonia is significantly different for the N9- and N7-alkylated guanine regioisomer pairs. More importantly, the abundance of the [MH-17] + ion is in linear correlation with the N9-isomer content. Therefore, the ratio of regioisomers can be determined in a mixture containing these compounds.

Original languageEnglish
Pages (from-to)236-240
Number of pages5
JournalRapid Communications in Mass Spectrometry
Volume19
Issue number2
DOIs
Publication statusPublished - Feb 10 2005

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry

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