Determination of emitted particle characteristics and upper airway deposition of Symbicort® Turbuhaler® dry powder inhaler

Sz Kugler, A. Nagy, A. Kerekes, M. Veres, I. Rigó, A. Czitrovszky

Research output: Contribution to journalArticle

Abstract

The mass median aerodynamic diameter (MMAD) of the particle ensemble released from Symbicort® Turbuhaler® dry powder inhaler and the aerosol particle volume size distribution in a realistic upper airway was studied experimentally, assuming different inhalation waveforms. The idealized waveforms were determined from the breathing parameters of 25 healthy voluntary adults who inhaled through a not activated Turbuhaler® device.The amount of particles available for lung deposition was quantified by numerical simulations with the help of the stochastic lung deposition model (SLDM). It was calculated that approximately 30% of the particles released from the DPI are deposited in the upper airway. The lung deposition of the drug from the DPI was calculated to be between 16% and 59% of the nominal dose. The peak inhalation flow and the inhalation volume were found to be the main factors affecting the efficiency of the deposition, the inhalation time has also a small effect on it.

Original languageEnglish
Article number101229
JournalJournal of Drug Delivery Science and Technology
Volume54
DOIs
Publication statusPublished - Dec 2019

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Keywords

  • Dry power inhaler
  • MMAD
  • Numerical modeling
  • Particle size distribution

ASJC Scopus subject areas

  • Pharmaceutical Science

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