Determination of drug-cyclodextrin binding constants by capillary zone electrophoresis

János Gyimesi, Éva Szöko, Kálmán Magyar, Lajos Barcza

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Binding constants of the optical isomers of Deprenyl® (selegiline) and its potential metabolites with (2,6-di-O-methyl)-β-cyclodextrin were determined using electrophoretic mobility data gained from separations performed by capillary electrophofesis, and absorbancies obtained from spectrophotometric experiments. To calculate equilibrium constants 1:1 complex formation have been assumed. The comparison of the equilibrium constants calculated from different methods shows similar values in their order of magnitude. Their difference may probably be explained by the different media of the measurements. The effect of the structure of compounds on chiral discrimination were also elucidated.

Original languageEnglish
Pages (from-to)253-256
Number of pages4
JournalJournal of Inclusion Phenomena and Molecular Recognition in Chemistry
Volume25
Issue number1-3
DOIs
Publication statusPublished - Jan 1 1996

ASJC Scopus subject areas

  • Food Science
  • Chemistry(all)
  • Condensed Matter Physics

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