Determination of clozapine and its N-desmethyl metabolite by high-performance liquid chromatography with ultraviolet detection

Adrián LLerena, R. Berecz, María Jesús Norberto, Alfredo De La Rubia

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A rapid high-performance liquid chromatographic method has been developed for the simultaneous determination of the atypical antipsychotic drug clozapine and its principal metabolite, N-desmethyl clozapine in human plasma. After liquid-liquid extraction the compounds were separated in a reversed-phase column and measured by ultraviolet absorption at 230 nm. For both compounds inter-day variations were

Original languageEnglish
Pages (from-to)349-354
Number of pages6
JournalJournal of Chromatography B: Biomedical Sciences and Applications
Volume755
Issue number1-2
DOIs
Publication statusPublished - May 5 2001

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Clozapine
High performance liquid chromatography
Metabolites
Liquids
Plasma (human)
Antipsychotic Agents

Keywords

  • Clozapine
  • N-desmethyl clozapine

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Determination of clozapine and its N-desmethyl metabolite by high-performance liquid chromatography with ultraviolet detection. / LLerena, Adrián; Berecz, R.; Norberto, María Jesús; De La Rubia, Alfredo.

In: Journal of Chromatography B: Biomedical Sciences and Applications, Vol. 755, No. 1-2, 05.05.2001, p. 349-354.

Research output: Contribution to journalArticle

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