Determination of absolute configuration of ketamine enantiomers by HPLC- CD-UV technique

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Recognizing that the stereochemical structure of NMDA receptor antagonist ketamine provides valuable data about the relationship between its conformation and absolute configuration by CD-UV analysis, a method for the identification of ketamine enantiomers is proposed which avoids the need for authentic samples of the enantiomers. The ketamine enantiomers were separated by HPLC using Chiralcel OJ stationary phase. The in situ registration of CD and UV spectra, together with the application of the octant rule for cyclohexanone derivatives, makes possible the direct assignment of the eluted ketamine enantiomers.

Original languageEnglish
Pages (from-to)741-744
Number of pages4
JournalChirality
Volume11
Issue number10
DOIs
Publication statusPublished - 1999

Fingerprint

Enantiomers
Ketamine
High Pressure Liquid Chromatography
N-Methyl-D-Aspartate Receptors
Conformations
Derivatives

Keywords

  • Absolute configuration
  • Chiroptical detector
  • HPLC
  • Ketamine enantiomers
  • Octant rule

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

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title = "Determination of absolute configuration of ketamine enantiomers by HPLC- CD-UV technique",
abstract = "Recognizing that the stereochemical structure of NMDA receptor antagonist ketamine provides valuable data about the relationship between its conformation and absolute configuration by CD-UV analysis, a method for the identification of ketamine enantiomers is proposed which avoids the need for authentic samples of the enantiomers. The ketamine enantiomers were separated by HPLC using Chiralcel OJ stationary phase. The in situ registration of CD and UV spectra, together with the application of the octant rule for cyclohexanone derivatives, makes possible the direct assignment of the eluted ketamine enantiomers.",
keywords = "Absolute configuration, Chiroptical detector, HPLC, Ketamine enantiomers, Octant rule",
author = "A. Gergely and F. Zsila and P. Horv{\'a}th and G. Sz{\'a}sz",
year = "1999",
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T1 - Determination of absolute configuration of ketamine enantiomers by HPLC- CD-UV technique

AU - Gergely, A.

AU - Zsila, F.

AU - Horváth, P.

AU - Szász, G.

PY - 1999

Y1 - 1999

N2 - Recognizing that the stereochemical structure of NMDA receptor antagonist ketamine provides valuable data about the relationship between its conformation and absolute configuration by CD-UV analysis, a method for the identification of ketamine enantiomers is proposed which avoids the need for authentic samples of the enantiomers. The ketamine enantiomers were separated by HPLC using Chiralcel OJ stationary phase. The in situ registration of CD and UV spectra, together with the application of the octant rule for cyclohexanone derivatives, makes possible the direct assignment of the eluted ketamine enantiomers.

AB - Recognizing that the stereochemical structure of NMDA receptor antagonist ketamine provides valuable data about the relationship between its conformation and absolute configuration by CD-UV analysis, a method for the identification of ketamine enantiomers is proposed which avoids the need for authentic samples of the enantiomers. The ketamine enantiomers were separated by HPLC using Chiralcel OJ stationary phase. The in situ registration of CD and UV spectra, together with the application of the octant rule for cyclohexanone derivatives, makes possible the direct assignment of the eluted ketamine enantiomers.

KW - Absolute configuration

KW - Chiroptical detector

KW - HPLC

KW - Ketamine enantiomers

KW - Octant rule

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