The histological grade of invasive breast cancers reflecting their differentiation is a proven prognostic marker, that may have its role in planning treatment. The belief of a poor reproducibility has prevented its wide use, this is why several changes have been made to improve the reproducibility. The article describes the modifications made in Nottingham to the most widely used scheme originated from Bloom and Richardson. It also gives illustrations essential for using this method. Besides methodology the article also describes some criticisms of histological grading, and its prognostic use as well as its relationship with other prognostic factors, eg. those related to proliferating activity, oncogenes, tumor suppressor genes and steroid hormon receptors.
|Number of pages||10|
|Journal||Lege Artis Medicinae|
|Publication status||Published - May 20 1996|
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