Determinants of aortic stiffness: 16-year follow-up of the Whitehall II study

Nanna B. Johansen, Dorte Vistisen, Eric J. Brunner, A. Tabák, Martin J. Shipley, Ian B. Wilkinson, Carmel M. McEniery, Michael Roden, Christian Herder, Mika Kivimäki, Daniel R. Witte

Research output: Contribution to journalArticle

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Abstract

Background: Aortic stiffness is a strong predictor of cardiovascular disease endpoints. Cross-sectional studies have shown associations of various cardiovascular risk factors with aortic pulse wave velocity, a measure of aortic stiffness, but the long-term impact of these factors on aortic stiffness is unknown. Methods: In 3,769 men and women from the Whitehall II cohort, a wide range of traditional and novel cardiovascular risk factors were determined at baseline (1991-1993) and aortic pulse wave velocity was measured at follow-up (2007-2009). The prospective associations between each baseline risk factor and aortic pulse wave velocity at follow-up were assessed through sex stratified linear regression analysis adjusted for relevant confounders. Missing data on baseline determinants were imputed using the Multivariate Imputation by Chained Equations. Results: Among men, the strongest predictors were waist circumference, waist-hip ratio, heart rate and interleukin 1 receptor antagonist, and among women, adiponectin, triglycerides, pulse pressure and waist-hip ratio. The impact of 10 centimeter increase in waist circumference on aortic pulse wave velocity was twice as large for men compared with women (men: 0.40 m/s (95%-CI: 0.24;0.56); women: 0.17 m/s (95%-CI: -0.01;0.35)), whereas the opposite was true for the impact of a two-fold increase in adiponectin (men: -0.30 m/s (95%-CI: -0.51;-0.10); women: 0.61 m/s (95%-CI: -0.86;-0.35)). Conclusion: In this large prospective study, central obesity was a strong predictor of aortic stiffness. Additionally, heart rate in men and adiponectin in women predicted aortic pulse wave velocity suggesting that strategies to prevent aortic stiffening should be focused differently by sex.

Original languageEnglish
Article numbere37165
JournalPLoS One
Volume7
Issue number5
DOIs
Publication statusPublished - May 22 2012

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Vascular Stiffness
Pulse Wave Analysis
Stiffness
Adiponectin
adiponectin
risk factors
Waist-Hip Ratio
waist
waist circumference
Waist Circumference
hips
heart rate
Heart Rate
Interleukin-1 Receptors
Linear regression
Abdominal Obesity
Regression analysis
gender
interleukin-1
prospective studies

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Johansen, N. B., Vistisen, D., Brunner, E. J., Tabák, A., Shipley, M. J., Wilkinson, I. B., ... Witte, D. R. (2012). Determinants of aortic stiffness: 16-year follow-up of the Whitehall II study. PLoS One, 7(5), [e37165]. https://doi.org/10.1371/journal.pone.0037165

Determinants of aortic stiffness : 16-year follow-up of the Whitehall II study. / Johansen, Nanna B.; Vistisen, Dorte; Brunner, Eric J.; Tabák, A.; Shipley, Martin J.; Wilkinson, Ian B.; McEniery, Carmel M.; Roden, Michael; Herder, Christian; Kivimäki, Mika; Witte, Daniel R.

In: PLoS One, Vol. 7, No. 5, e37165, 22.05.2012.

Research output: Contribution to journalArticle

Johansen, NB, Vistisen, D, Brunner, EJ, Tabák, A, Shipley, MJ, Wilkinson, IB, McEniery, CM, Roden, M, Herder, C, Kivimäki, M & Witte, DR 2012, 'Determinants of aortic stiffness: 16-year follow-up of the Whitehall II study', PLoS One, vol. 7, no. 5, e37165. https://doi.org/10.1371/journal.pone.0037165
Johansen NB, Vistisen D, Brunner EJ, Tabák A, Shipley MJ, Wilkinson IB et al. Determinants of aortic stiffness: 16-year follow-up of the Whitehall II study. PLoS One. 2012 May 22;7(5). e37165. https://doi.org/10.1371/journal.pone.0037165
Johansen, Nanna B. ; Vistisen, Dorte ; Brunner, Eric J. ; Tabák, A. ; Shipley, Martin J. ; Wilkinson, Ian B. ; McEniery, Carmel M. ; Roden, Michael ; Herder, Christian ; Kivimäki, Mika ; Witte, Daniel R. / Determinants of aortic stiffness : 16-year follow-up of the Whitehall II study. In: PLoS One. 2012 ; Vol. 7, No. 5.
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abstract = "Background: Aortic stiffness is a strong predictor of cardiovascular disease endpoints. Cross-sectional studies have shown associations of various cardiovascular risk factors with aortic pulse wave velocity, a measure of aortic stiffness, but the long-term impact of these factors on aortic stiffness is unknown. Methods: In 3,769 men and women from the Whitehall II cohort, a wide range of traditional and novel cardiovascular risk factors were determined at baseline (1991-1993) and aortic pulse wave velocity was measured at follow-up (2007-2009). The prospective associations between each baseline risk factor and aortic pulse wave velocity at follow-up were assessed through sex stratified linear regression analysis adjusted for relevant confounders. Missing data on baseline determinants were imputed using the Multivariate Imputation by Chained Equations. Results: Among men, the strongest predictors were waist circumference, waist-hip ratio, heart rate and interleukin 1 receptor antagonist, and among women, adiponectin, triglycerides, pulse pressure and waist-hip ratio. The impact of 10 centimeter increase in waist circumference on aortic pulse wave velocity was twice as large for men compared with women (men: 0.40 m/s (95{\%}-CI: 0.24;0.56); women: 0.17 m/s (95{\%}-CI: -0.01;0.35)), whereas the opposite was true for the impact of a two-fold increase in adiponectin (men: -0.30 m/s (95{\%}-CI: -0.51;-0.10); women: 0.61 m/s (95{\%}-CI: -0.86;-0.35)). Conclusion: In this large prospective study, central obesity was a strong predictor of aortic stiffness. Additionally, heart rate in men and adiponectin in women predicted aortic pulse wave velocity suggesting that strategies to prevent aortic stiffening should be focused differently by sex.",
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AU - Johansen, Nanna B.

AU - Vistisen, Dorte

AU - Brunner, Eric J.

AU - Tabák, A.

AU - Shipley, Martin J.

AU - Wilkinson, Ian B.

AU - McEniery, Carmel M.

AU - Roden, Michael

AU - Herder, Christian

AU - Kivimäki, Mika

AU - Witte, Daniel R.

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N2 - Background: Aortic stiffness is a strong predictor of cardiovascular disease endpoints. Cross-sectional studies have shown associations of various cardiovascular risk factors with aortic pulse wave velocity, a measure of aortic stiffness, but the long-term impact of these factors on aortic stiffness is unknown. Methods: In 3,769 men and women from the Whitehall II cohort, a wide range of traditional and novel cardiovascular risk factors were determined at baseline (1991-1993) and aortic pulse wave velocity was measured at follow-up (2007-2009). The prospective associations between each baseline risk factor and aortic pulse wave velocity at follow-up were assessed through sex stratified linear regression analysis adjusted for relevant confounders. Missing data on baseline determinants were imputed using the Multivariate Imputation by Chained Equations. Results: Among men, the strongest predictors were waist circumference, waist-hip ratio, heart rate and interleukin 1 receptor antagonist, and among women, adiponectin, triglycerides, pulse pressure and waist-hip ratio. The impact of 10 centimeter increase in waist circumference on aortic pulse wave velocity was twice as large for men compared with women (men: 0.40 m/s (95%-CI: 0.24;0.56); women: 0.17 m/s (95%-CI: -0.01;0.35)), whereas the opposite was true for the impact of a two-fold increase in adiponectin (men: -0.30 m/s (95%-CI: -0.51;-0.10); women: 0.61 m/s (95%-CI: -0.86;-0.35)). Conclusion: In this large prospective study, central obesity was a strong predictor of aortic stiffness. Additionally, heart rate in men and adiponectin in women predicted aortic pulse wave velocity suggesting that strategies to prevent aortic stiffening should be focused differently by sex.

AB - Background: Aortic stiffness is a strong predictor of cardiovascular disease endpoints. Cross-sectional studies have shown associations of various cardiovascular risk factors with aortic pulse wave velocity, a measure of aortic stiffness, but the long-term impact of these factors on aortic stiffness is unknown. Methods: In 3,769 men and women from the Whitehall II cohort, a wide range of traditional and novel cardiovascular risk factors were determined at baseline (1991-1993) and aortic pulse wave velocity was measured at follow-up (2007-2009). The prospective associations between each baseline risk factor and aortic pulse wave velocity at follow-up were assessed through sex stratified linear regression analysis adjusted for relevant confounders. Missing data on baseline determinants were imputed using the Multivariate Imputation by Chained Equations. Results: Among men, the strongest predictors were waist circumference, waist-hip ratio, heart rate and interleukin 1 receptor antagonist, and among women, adiponectin, triglycerides, pulse pressure and waist-hip ratio. The impact of 10 centimeter increase in waist circumference on aortic pulse wave velocity was twice as large for men compared with women (men: 0.40 m/s (95%-CI: 0.24;0.56); women: 0.17 m/s (95%-CI: -0.01;0.35)), whereas the opposite was true for the impact of a two-fold increase in adiponectin (men: -0.30 m/s (95%-CI: -0.51;-0.10); women: 0.61 m/s (95%-CI: -0.86;-0.35)). Conclusion: In this large prospective study, central obesity was a strong predictor of aortic stiffness. Additionally, heart rate in men and adiponectin in women predicted aortic pulse wave velocity suggesting that strategies to prevent aortic stiffening should be focused differently by sex.

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