Detection of volatile compounds correlated to human diseases through breath analysis with chemical sensors

Maximilian Fleischer, Elfriede Simon, Eva Rumpel, Heiko Ulmer, Mika Harbeck, Michael Wandel, Christopher Fietzek, Udo Weimar, H. Meixner

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

The analysis of volatile compounds in the breath of humans was investigated by the application of different sensor principles. The detection of nitrogen oxide, an asthma marker, in breath at the low ppb-level (2-100ppb) can be carried out by work function measurements. By the use of Cu-phthalocyanine dye as gas sensitive layer a calculated detection limit of 1.3ppb is attainable. The low cross sensitivities to water and changes in the oxygen concentration are of great advantage for the use in breath analysis. With quartz microbalance (QMB) measurements acetone concentrations, a marker for diabetes, can be determined in the presence of ethanol and water vapor. The comparison of both sensor principles showed no correlation, hence, the combination can improve cross sensitivity and sensor selectivity.

Original languageEnglish
Pages (from-to)245-249
Number of pages5
JournalSensors and Actuators, B: Chemical
Volume83
Issue number1-3
DOIs
Publication statusPublished - Mar 15 2002

Fingerprint

Chemical sensors
markers
sensors
Sensors
asthma
Quartz
nitrogen oxides
sensitivity
Steam
Nitrogen oxides
Medical problems
Acetone
microbalances
Water vapor
acetone
water vapor
Nitric Oxide
Ethanol
ethyl alcohol
Coloring Agents

Keywords

  • Breath analysis
  • Kelvin probe measurements
  • Quartz microbalance
  • Volatile compounds

ASJC Scopus subject areas

  • Analytical Chemistry
  • Electrochemistry
  • Electrical and Electronic Engineering

Cite this

Detection of volatile compounds correlated to human diseases through breath analysis with chemical sensors. / Fleischer, Maximilian; Simon, Elfriede; Rumpel, Eva; Ulmer, Heiko; Harbeck, Mika; Wandel, Michael; Fietzek, Christopher; Weimar, Udo; Meixner, H.

In: Sensors and Actuators, B: Chemical, Vol. 83, No. 1-3, 15.03.2002, p. 245-249.

Research output: Contribution to journalArticle

Fleischer, M, Simon, E, Rumpel, E, Ulmer, H, Harbeck, M, Wandel, M, Fietzek, C, Weimar, U & Meixner, H 2002, 'Detection of volatile compounds correlated to human diseases through breath analysis with chemical sensors', Sensors and Actuators, B: Chemical, vol. 83, no. 1-3, pp. 245-249. https://doi.org/10.1016/S0925-4005(01)01056-5
Fleischer, Maximilian ; Simon, Elfriede ; Rumpel, Eva ; Ulmer, Heiko ; Harbeck, Mika ; Wandel, Michael ; Fietzek, Christopher ; Weimar, Udo ; Meixner, H. / Detection of volatile compounds correlated to human diseases through breath analysis with chemical sensors. In: Sensors and Actuators, B: Chemical. 2002 ; Vol. 83, No. 1-3. pp. 245-249.
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