Detection of P-glycoprotein in human leukemias using monoclonal antibodies

J. Mattern, T. Efferth, M. Bak, A. D. Ho, M. Volm

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23 Citations (Scopus)

Abstract

Overexpression of a Mr 170,000 membrane glycoprotein (P-glycoprotein) is consistently associated with multidrug resistance in cell lines. Two monoclonal antibodies (Mab) against P-glycoprotein (265/F4 and C 219) were used to examine tumour samples from patients with leukemias for evidence of P-glycoprotein overexpression. High levels of P-glycoprotein (>5% positive cells) were detected with both antibodies in samples from 3 out of 18 patients suggesting that a multidrug resistant phenotype may also occur in human leukemias.

Original languageEnglish
Pages (from-to)215-217
Number of pages3
JournalBlut
Volume58
Issue number4
DOIs
Publication statusPublished - Apr 1 1989

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Keywords

  • Leukemia
  • Monoclonal antibody
  • Multi-drug resistance
  • P-glycoprotein

ASJC Scopus subject areas

  • Hematology

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