Detection of low molecular weight toxins using optical phase detection techniques

A. Nabok, A. Tsargorodskaya, M. K. Mustafa, A. Székács, I. Székács, N. F. Starodub

Research output: Contribution to journalConference article

4 Citations (Scopus)

Abstract

Optical methods based on recording a phase shift of electromagnetic waves offer high sensitivity for detection of bio-reactions. The method of Total Internal Reflection Ellipsometry (TIRE), which records simultaneously two parameters Ψ and Δ related, respectively, to the amplitudes and phases of p- and s-components of polarized light, was exploited here for detection of mycotoxins (T-2, zearalanone, and aflatoxin). The TIRE direct label-free immunoassay enables detecting the above mycotoxins in sub-ppb concentrations in water as well as in food extracts. Further enhancement of sensitivity can be achieved with the use of SiO2/Si3N4/SiO2 planar waveguides operating as polarization interferometers (PI).

Original languageEnglish
Pages (from-to)1491-1494
Number of pages4
JournalProcedia Chemistry
Volume1
Issue number1
DOIs
Publication statusPublished - Sep 1 2009
EventEurosensors 23rd Conference - Lausanne, Switzerland
Duration: Sep 6 2009Sep 9 2009

Keywords

  • direct immunoassay
  • mycotoxins
  • planar waveguide
  • polarization interferometry
  • total internal reflection ellipsometry

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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  • Cite this

    Nabok, A., Tsargorodskaya, A., Mustafa, M. K., Székács, A., Székács, I., & Starodub, N. F. (2009). Detection of low molecular weight toxins using optical phase detection techniques. Procedia Chemistry, 1(1), 1491-1494. https://doi.org/10.1016/j.proche.2009.07.372