Detection of long-term ototoxic effect of antitumour chemotherapy by transiently evoked otoemission - A pilot study (effect of cisplatin on the cochlea)

T. Rácz, L. Toth, I. Lampé, L. Noszek, B. Büki, O. Ribári

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The aim of this study was to detect changes of transient evoked otoemissions during long-term chemotherapy with cisplatin. Ten female patients were tested before and after one week of cytostatic therapy and 15 female patients were tested before and after treatment consisting of 75 mg/m2 cisplatin and 750 mg/m2 cyclophosphamide administrated by intravenous infusion four times during four months (once every four weeks). The measurements were carried out before therapy and after the completed four months. In the first group no significant changes of otoemission amplitude were found, but in the second group a slight but significant decrease of amplitude could be demonstrated. The results of conventional audiometry showed no changes after therapy. The decrease of amplitude may be an early sign of ototoxic effects on the outer hair cells. We conclude that the measurement of otoemissions is a simple, non-invasive method to detect hearing impairment due to cisplatin ototoxicity.

Original languageEnglish
Pages (from-to)58-63
Number of pages6
JournalJournal of Audiological Medicine
Volume7
Issue number1
Publication statusPublished - Jan 1 1998

Keywords

  • Cisplatin
  • Ototoxicity
  • Transient otoemission

ASJC Scopus subject areas

  • Otorhinolaryngology

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