Detection of glutathione S-transferase antigen expression in testicular carcinomas

N. Hanna Eid, E. Institoris, I. Bodrogi, J. Kondas, M. Bak

Research output: Contribution to journalArticle

Abstract

Drug resistance in human tumors is undoubtedly multifactorial, and several mechanisms including alterations on glutathione associated enzymes, P-glycoprotein may coexist. Expression of glutathione S-transferase-pi antigen was screened in 55 untreated human germinal cell testicular tumors using polyclonal antibody and immunoenzyme staining. In samples out of 17 seminomatous tumors 1 seminoma, and out of 38 non-seminomatous tumors 15 teratomas showed high expression of glutathione S-transferase-pi antigen. Our results suggest that glutathione S-transferase-pi similar to P-glycoprotein may also occur and might contribute to drug resistance in germ cell testicular tumors.

Original languageEnglish
Pages (from-to)149-156
Number of pages8
JournalMagyar Urologia
Volume6
Issue number2
Publication statusPublished - Jan 1 1994

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Keywords

  • Drug resistance
  • Glutathione transferases
  • Testicular neoplasms

ASJC Scopus subject areas

  • Urology

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