Detection of four lymphotropic herpesviruses in Hungarian Patients with multiple myeloma and lymphoma

Márta Csire, G. Mikala, Mónika Peto, Judit Jánosi, A. Juhász, A. Tordai, János Jákó, Gyula Domján, János Dolgos, G. Berencsi, István Vályi-Nagy

Research output: Contribution to journalArticle

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Abstract

It has been suggested that human herpesvirus 8 (HHV-8), also known as KSHV (Kaposi's sarcoma-associated human herpesvirus), might possess a promoting effect in the development and progression of monoclonal gammopathies. In this study, the presence of Epstein-Barr virus (EBV), human cytomegalovirus (CMV), human herpesvirus 6 (HHV-6) and human herpesvirus 8 (HHV-8) were tested in patients with multiple myeloma (MM) using both serologic and nucleic acid amplification techniques. The transient reactivation or continuous presence of EBV, CMV, HHV-6 and HHV-8 could be detected in, respectively, 36, eight, 13 and 29 of 69 MM patients; nine, one, four and six of 16 monoclonal gammopathy of unknown significance patients; and seven, four, zero and five of 10 Waldenström's macroglobulinemia patients. The total number of MM patients was 95. HHV-8 PCR-positivity was significantly more frequent in the MM group than in the control group of patients with non-Hodgkin's lymphoma (NHL). However, serologic testing did not reveal significant differences between the two patient groups. The number of MM patients with concomitant herpesvirus infections as detected by PCR was as follows: 15 double, seven triple and two quadruple virus nucleic acid positive. In 13/95 MM patients, the simultaneous presence of acute EBV infection and HHV-8 PCR-positivity was detected compared with none of the control group (P=0.009). These results indicate that in addition to HHV-8, the transitional reactivation of EBV may also play a role in the pathogenesis of MM.

Original languageEnglish
Pages (from-to)62-67
Number of pages6
JournalFEMS Immunology and Medical Microbiology
Volume49
Issue number1
DOIs
Publication statusPublished - Feb 2007

Fingerprint

Herpesviridae
Multiple Myeloma
Human Herpesvirus 8
Lymphoma
Human Herpesvirus 4
Human Herpesvirus 6
Paraproteinemias
Cytomegalovirus
Polymerase Chain Reaction
Nucleic Acid Amplification Techniques
Waldenstrom Macroglobulinemia
Herpesviridae Infections
Control Groups
Epstein-Barr Virus Infections
Non-Hodgkin's Lymphoma
Nucleic Acids
Viruses

Keywords

  • HHV-8
  • Lymphotropic herpesviruses
  • Multiple myeloma
  • Non-Hodgkin's lymphoma
  • Waldenström macroglobulinemia

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Infectious Diseases

Cite this

Detection of four lymphotropic herpesviruses in Hungarian Patients with multiple myeloma and lymphoma. / Csire, Márta; Mikala, G.; Peto, Mónika; Jánosi, Judit; Juhász, A.; Tordai, A.; Jákó, János; Domján, Gyula; Dolgos, János; Berencsi, G.; Vályi-Nagy, István.

In: FEMS Immunology and Medical Microbiology, Vol. 49, No. 1, 02.2007, p. 62-67.

Research output: Contribution to journalArticle

Csire, Márta ; Mikala, G. ; Peto, Mónika ; Jánosi, Judit ; Juhász, A. ; Tordai, A. ; Jákó, János ; Domján, Gyula ; Dolgos, János ; Berencsi, G. ; Vályi-Nagy, István. / Detection of four lymphotropic herpesviruses in Hungarian Patients with multiple myeloma and lymphoma. In: FEMS Immunology and Medical Microbiology. 2007 ; Vol. 49, No. 1. pp. 62-67.
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