Detection of factor V Leiden mutation in severe pre-eclamptic Hungarian women

Research output: Contribution to journalArticle

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Abstract

Pre-eclampsia is a pregnancy-related disorder that complicates approximately 5% of all pregnancies and is cited as the primary cause of worldwide maternal and fetal mortality. The factor V Leiden mutation has been implicated in the development of severe pre-eclampsia. In order to investigate this association, a sample of 198 Hungarian women was recruited and enrolled in one of the three groups based on reproductive and health status: those as classified as pregnant and healthy (n = 71), those diagnosed as pregnant and severe pre-eclamptic (n = 69), and those found to be healthy and non-pregnant (n = 58. The presence of factor V Leiden mutation was determined by using polymerase chain reaction (PCR) followed by restriction fragment length polymorphism analysis (RFLP). We identified three (5.2%) heterozygous among healthy non-pregnant participants, five (7.0%) heterozygous among healthy pregnant participants and 13 (18.8%) heterozygous among pre-eclamptic women (p <0.05, 95% CI). Our result supports the previous observation that carriers of factor V Leiden mutation are at increased risk for developing severe pre-eclampsia.

Original languageEnglish
Pages (from-to)478-481
Number of pages4
JournalClinical Genetics
Volume53
Issue number6
Publication statusPublished - Jun 1998

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Pre-Eclampsia
Mutation
Fetal Mortality
Pregnancy
Maternal Mortality
Reproductive Health
Restriction Fragment Length Polymorphisms
Health Status
Healthy Volunteers
Polymerase Chain Reaction
factor V Leiden

Keywords

  • Genetics
  • Leiden mutation
  • PCR
  • Pre-eclampsia
  • Pregnancy

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Detection of factor V Leiden mutation in severe pre-eclamptic Hungarian women. / Nagy, B.; Tóth, T.; Rigó, J.; Karádi, I.; Romics, László; Papp, Z.

In: Clinical Genetics, Vol. 53, No. 6, 06.1998, p. 478-481.

Research output: Contribution to journalArticle

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