Detection of early glaucomatous progression with different parameters of the RTVue optical coherence tomograph

Farzaneh Naghizadeh, Anita Garas, Péter Vargha, Gábor Holló

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

PURPOSE:: To investigate the ability of different parameters of the RTVue-100 Fourier-domain optical coherence tomograph (RTVue-OCT) to detect early glaucomatous progression. METHODS:: One eye of 17 healthy and 51 perimetric glaucoma patients was imaged prospectively at 6-month intervals for 1.5 to 3 years. Progression was determined by Octopus normal G2 visual field progression criteria. RESULTS:: Ten of the 51 glaucoma eyes progressed based on visual field criteria. Median visual field mean defect change was -0.300 dB/y for the controls, -0.120 dB/y for all glaucoma eyes (P=0.461 vs. controls), and 1.231 dB/y for the 10 functionally progressing glaucoma eyes (P<0.001 vs. controls). Ganglion cell complex (GCC), focal loss volume, and GCC global loss volume showed significantly faster rate of progression in the glaucoma group than in controls (P=0.004 and P=0.001, respectively). No optic nerve head, retinal nerve fiber layer thickness, and average GCC parameter separated the rate of progression between the groups. CONCLUSIONS:: Early structural progression of glaucoma may be better detected with pattern-based GCC parameters of the RTVue-OCT than with the optic nerve head, retinal nerve fiber layer thickness or average GCC parameters of the same instrument.

Original languageEnglish
Pages (from-to)195-198
Number of pages4
JournalJournal of glaucoma
Volume23
Issue number4
DOIs
Publication statusPublished - Jan 1 2014

Keywords

  • Ganglion cell complex
  • Glaucoma
  • Progression of glaucoma
  • RTVue Fourier-domain OCT
  • Retinal nerve fiber layer

ASJC Scopus subject areas

  • Ophthalmology

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