Detection and measurement of neurofibromatosis-1 mouse optic glioma in vivo

Debasish Banerjee, Balazs Hegedus, David H. Gutmann, Joel R. Garbow

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

One of the major limitations to preclinical mouse therapeutic evaluation is the inherent difficulty in imaging small tumors in vivo. We present a rapid and reliable method to detect optic glioma (OPG) in a mouse neurofibromatosis-1 model (Nf1flox/mutGFAP-Cre mice) in vivo using Manganese-Enhanced Magnetic Resonance Imaging (MEMRI). In a blinded study, 23 mice were chosen randomly from a cohort of Nf1flox/mutGFAP-Cre mice and two sets of age-matched controls. In all cases, OPG presence or absence was correctly identified. In addition, the OPG size and shape were accurately measured in vivo, facilitating the use of this model for preclinical drug studies.

Original languageEnglish
Pages (from-to)1434-1437
Number of pages4
JournalNeuroImage
Volume35
Issue number4
DOIs
Publication statusPublished - May 1 2007

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ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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