INTRODUCTION - When using percutaneous non-steroidal antiinflammatory drugs a good level of clinical effect and local cyclooxigenase inhibition equal to the use of oral drug administration can be achieved, while getting a lower serum level and having lower side effects. Iontophoresis allows the amount of medicine intake to be increased. Percutaneous NSAID treatment is suitable for decreasing the inflammation of the superficial joints. In spite of this fact there are few studies evaluating the synovial concentration of NSAIDs after the iontophoretic treatment. PATIENTS AND METHODSTHODS - The penetration of etofenamate by means of iontophoresis was examined. Iontophoresis was applied on five consecutive days, with a twenty minute duration, to the lumbar region of eleven patients suffering from lower back pain, and to the knee of thirteen patients suffering from chronic synovitis. After the fifth treatment the serum and synovial etofenamate levels were measured with high pressure liquid cromatography. RESULTS - The drug was detected in the plasma, and in the synovial fluid respectively, and twice with higher concentration in the latter one. CONCLUSION - The authors suggest that etofenamate is an effective topical therapy instead of dionin, lidocaine and novocain to treat patients who have inflammation of the underlying soft tissues.
|Number of pages||4|
|Journal||Lege Artis Medicinae|
|Publication status||Published - May 3 1999|
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