DESOGESTREL - SZELEKTIV PROGESZTERON AS ORALIS FOGAMZASGATLASBAN

Translated title of the contribution: Desogestrel - progestin selectivity in oral contraception

Research output: Contribution to journalArticle

Abstract

Oral contraceptive pills introduced in the sixties had significant side effects due to their high hormone content. The incidence of cardiovascular and thromboembolic complications are associated with the dose of estrogen component, while the increased risk of ischemic heart disease is due to the adverse effect of progestin component on the lipid profile. In order to decrease side effects, estrogen dosage has been developed. The first representative of this new generation is desogestrel having 3-keto-desogestrel as active metabolite. Receptor binding studies have proved that among the most widely used progestins desogestrel has the highest progestin selectivity with high progestational and low androgenic activity. It may also be proved with the high selectivity index (the ratio between the relative affinity for the progesterone receptor and androgen receptor). Due to their high selectivity, oral contraceptives containing desogestrel have neglectable side effects, have no adverse effects on lipid and carbohydrate metabolism, and improve clinical signs of hyperandrogenemia.

Original languageHungarian
Pages (from-to)13-18
Number of pages6
JournalMagyar Noorvosok Lapja
Volume58
Issue number3 SUPPL.
Publication statusPublished - 1995

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Desogestrel
Progestins
Contraception
Oral Contraceptives
Estrogens
Carbohydrate Metabolism
Androgen Receptors
Progesterone Receptors
Lipid Metabolism
Myocardial Ischemia
Hormones
Lipids
Incidence

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

DESOGESTREL - SZELEKTIV PROGESZTERON AS ORALIS FOGAMZASGATLASBAN. / Szabó, I.

In: Magyar Noorvosok Lapja, Vol. 58, No. 3 SUPPL., 1995, p. 13-18.

Research output: Contribution to journalArticle

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