Translated title of the contribution: Desogestrel - progestin selectivity in oral contraception

Research output: Contribution to journalArticle


Oral contraceptive pills introduced in the sixties had significant side effects due to their high hormone content. The incidence of cardiovascular and thromboembolic complications are associated with the dose of estrogen component, while the increased risk of ischemic heart disease is due to the adverse effect of progestin component on the lipid profile. In order to decrease side effects, estrogen dosage has been developed. The first representative of this new generation is desogestrel having 3-keto-desogestrel as active metabolite. Receptor binding studies have proved that among the most widely used progestins desogestrel has the highest progestin selectivity with high progestational and low androgenic activity. It may also be proved with the high selectivity index (the ratio between the relative affinity for the progesterone receptor and androgen receptor). Due to their high selectivity, oral contraceptives containing desogestrel have neglectable side effects, have no adverse effects on lipid and carbohydrate metabolism, and improve clinical signs of hyperandrogenemia.

Translated title of the contributionDesogestrel - progestin selectivity in oral contraception
Original languageHungarian
Pages (from-to)13-18
Number of pages6
JournalMagyar Noorvosok Lapja
Issue number3 SUPPL.
Publication statusPublished - Jan 1 1995

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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