A typical case of desmoplastic small round cell tumour of the pleura in a 25-year-old man is described. In addition to the typical histological and immunohistological findings, the EWS-WT1 fusion product was also observed. Ultrastructurally, some tumour cells displayed intracytoplasmic neolumina, with short microvilli characteristic of submesothelial cells. These findings support the theory of a splanchnopleurie intraembryonic mesodermal, 'mesothelioblastemic' origin, both morphologically and cytogenetically.
- Desmoplastic small round cell tumour
- EWS-WT1 fusion gene
- Intracytoplasmic neolumina
ASJC Scopus subject areas