Desmoplastic small round cell tumour of the pleura: A case report with further cytogenetic and ultrastructural evidence of 'mesothelioblastemic' origin

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Abstract

A typical case of desmoplastic small round cell tumour of the pleura in a 25-year-old man is described. In addition to the typical histological and immunohistological findings, the EWS-WT1 fusion product was also observed. Ultrastructurally, some tumour cells displayed intracytoplasmic neolumina, with short microvilli characteristic of submesothelial cells. These findings support the theory of a splanchnopleurie intraembryonic mesodermal, 'mesothelioblastemic' origin, both morphologically and cytogenetically.

Original languageEnglish
Pages (from-to)633-634
Number of pages2
JournalEuropean Journal of Surgical Oncology
Volume25
Issue number6
DOIs
Publication statusPublished - Dec 1999

Keywords

  • Desmoplastic small round cell tumour
  • EWS-WT1 fusion gene
  • Intracytoplasmic neolumina
  • Pleura

ASJC Scopus subject areas

  • Surgery
  • Oncology

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