Designed nucleophilic attack based on molecular electrostatic potential

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9 Citations (Scopus)


We describe the computer-aided design of the steric preference in a nucleophilic attack on sterically unbiased carbonyl groups. To our knowledge, this is the first example for the successful application of the molecular electrostatic potential map to computer-assisted synthesis.

Original languageEnglish
Pages (from-to)9255-9258
Number of pages4
JournalTetrahedron Letters
Issue number49
Publication statusPublished - Dec 5 1994

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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