Design, realisation and validation of microfluidic stochastic mixers integrable in bioanalytical systems using CFD modeling

E. Toth, K. Ivan, P. Fürjes, Z. Fekete, E. G. Holczer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

In this work we present the design aspects of special microfluidic structures applicable to dilute and transport analyte solutions (such as whole blood) to the sensing area of biosensors. Our goal is to design and realise a reliable microfluidic system which is applicable for effective sample transport and can accomplish simple sample preparation functions such as mixing to ensure homogeneous concentration distribution of the species along the fluidic channel. The behaviour of different chaotic mixers were analysed by numerical modeling and experimentally to determine their efficiency. At first we used the concentration distribution method, however because of numerical diffusion this required higher mesh resolutions. Using the particle tracing method is more efficient according to the experimental results and requires lower computational effort. The microstructures were realised by micro-fabrication in polydimethylsiloxane (PDMS) and integrated into a real microfluidic transport system. The functional performance was verified by biological analyte.

Original languageEnglish
Title of host publication2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013
Pages266-269
Number of pages4
DOIs
Publication statusPublished - 2013
Event2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013 - Rotterdam, Netherlands
Duration: Oct 31 2013Nov 2 2013

Other

Other2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013
CountryNetherlands
CityRotterdam
Period10/31/1311/2/13

Fingerprint

Microfluidics
Computational fluid dynamics
Microfabrication
Fluidics
Polydimethylsiloxane
Biosensors
Blood
Microstructure

Keywords

  • chaotic advection
  • computational fluid dynamics (CFD)
  • lab-on-a-chip
  • micromixers
  • polymer microfluidics

ASJC Scopus subject areas

  • Hardware and Architecture
  • Biomedical Engineering
  • Electrical and Electronic Engineering

Cite this

Toth, E., Ivan, K., Fürjes, P., Fekete, Z., & Holczer, E. G. (2013). Design, realisation and validation of microfluidic stochastic mixers integrable in bioanalytical systems using CFD modeling. In 2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013 (pp. 266-269). [6679690] https://doi.org/10.1109/BioCAS.2013.6679690

Design, realisation and validation of microfluidic stochastic mixers integrable in bioanalytical systems using CFD modeling. / Toth, E.; Ivan, K.; Fürjes, P.; Fekete, Z.; Holczer, E. G.

2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013. 2013. p. 266-269 6679690.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Toth, E, Ivan, K, Fürjes, P, Fekete, Z & Holczer, EG 2013, Design, realisation and validation of microfluidic stochastic mixers integrable in bioanalytical systems using CFD modeling. in 2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013., 6679690, pp. 266-269, 2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013, Rotterdam, Netherlands, 10/31/13. https://doi.org/10.1109/BioCAS.2013.6679690
Toth E, Ivan K, Fürjes P, Fekete Z, Holczer EG. Design, realisation and validation of microfluidic stochastic mixers integrable in bioanalytical systems using CFD modeling. In 2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013. 2013. p. 266-269. 6679690 https://doi.org/10.1109/BioCAS.2013.6679690
Toth, E. ; Ivan, K. ; Fürjes, P. ; Fekete, Z. ; Holczer, E. G. / Design, realisation and validation of microfluidic stochastic mixers integrable in bioanalytical systems using CFD modeling. 2013 IEEE Biomedical Circuits and Systems Conference, BioCAS 2013. 2013. pp. 266-269
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