Design of synthetic branched-chain polypeptides as carriers for bioactive molecules

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

New groups of synthetic biodegradable branched chain polypeptides have been prepared with the general formula poly[Lys-(X(i)-DL-Ala(m))] [XAK] or poly-(DL-(DL-Ala(m)-X(i))] [AXK], where m- 3 and i123I, 111In, 51Cr) or therapy (e.g. 153Sm, 131I) or (ii) the construction of synthetic antigens with peptide epitopes of mucin or Herpes Simplex virus glycoprotein D. Principles applicable for a rational carrier design are outlined based on chemical (size, charge, solution conformation) and biological (cytotoxicity, pirogenicity, biodegradation, immunogenicity, immunomodulatory potential, biodistribution) characterization of these biopolymers and their conjugates.

Original languageEnglish
Pages (from-to)171-193
Number of pages23
JournalAnti-Cancer Drugs
Volume6
Issue number2
Publication statusPublished - 1995

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Peptides
Synthetic Vaccines
Biopolymers
Mucins
Simplexvirus
Epitopes
Glycoproteins
Therapeutics

Keywords

  • Antitumor agent
  • Branched-chain polypeptide
  • Carrier
  • Conjugate

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pharmacology

Cite this

Design of synthetic branched-chain polypeptides as carriers for bioactive molecules. / Hudecz, F.

In: Anti-Cancer Drugs, Vol. 6, No. 2, 1995, p. 171-193.

Research output: Contribution to journalArticle

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