Design and synthesis of novel type somatostatin analogs with antiproliferative activities on A431 tumor cells

Anna Miyazaki, Toshio Yokoi, Yoshifumi Tachibana, Riyo Enomoto, Eibai Lee, Gyongyi Bokonyi, G. Kéri, Yuko Tsuda, Yoshio Okada

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

It was reported that the somatostatin analog TT-232, d-Phe-c(Cys-Tyr-d-Trp- Lys-Cys)-Thr-NH 2, exhibited a highly potent antitumor activity in vitro and in vivo. Using pyrazinone analogs and aliphatic amino acids instead of the disulfide bond, we prepared novel type somatostatin analogs including the sequence essential for antitumor activities, Tyr-d-Trp-Lys. These analogs exhibited antiproliferative effect on A431 tumor cells.

Original languageEnglish
Pages (from-to)6323-6327
Number of pages5
JournalTetrahedron Letters
Volume45
Issue number33
DOIs
Publication statusPublished - Aug 9 2004

Fingerprint

Somatostatin
cysteinyltyrosine
Tumors
Cells
Dilatation and Curettage
Disulfides
Neoplasms
Fatty Acids
Amino Acids
TT2-32
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Miyazaki, A., Yokoi, T., Tachibana, Y., Enomoto, R., Lee, E., Bokonyi, G., ... Okada, Y. (2004). Design and synthesis of novel type somatostatin analogs with antiproliferative activities on A431 tumor cells. Tetrahedron Letters, 45(33), 6323-6327. https://doi.org/10.1016/j.tetlet.2004.06.105

Design and synthesis of novel type somatostatin analogs with antiproliferative activities on A431 tumor cells. / Miyazaki, Anna; Yokoi, Toshio; Tachibana, Yoshifumi; Enomoto, Riyo; Lee, Eibai; Bokonyi, Gyongyi; Kéri, G.; Tsuda, Yuko; Okada, Yoshio.

In: Tetrahedron Letters, Vol. 45, No. 33, 09.08.2004, p. 6323-6327.

Research output: Contribution to journalArticle

Miyazaki, A, Yokoi, T, Tachibana, Y, Enomoto, R, Lee, E, Bokonyi, G, Kéri, G, Tsuda, Y & Okada, Y 2004, 'Design and synthesis of novel type somatostatin analogs with antiproliferative activities on A431 tumor cells', Tetrahedron Letters, vol. 45, no. 33, pp. 6323-6327. https://doi.org/10.1016/j.tetlet.2004.06.105
Miyazaki, Anna ; Yokoi, Toshio ; Tachibana, Yoshifumi ; Enomoto, Riyo ; Lee, Eibai ; Bokonyi, Gyongyi ; Kéri, G. ; Tsuda, Yuko ; Okada, Yoshio. / Design and synthesis of novel type somatostatin analogs with antiproliferative activities on A431 tumor cells. In: Tetrahedron Letters. 2004 ; Vol. 45, No. 33. pp. 6323-6327.
@article{5753599108d44c34a3a4bd35a83c1e10,
title = "Design and synthesis of novel type somatostatin analogs with antiproliferative activities on A431 tumor cells",
abstract = "It was reported that the somatostatin analog TT-232, d-Phe-c(Cys-Tyr-d-Trp- Lys-Cys)-Thr-NH 2, exhibited a highly potent antitumor activity in vitro and in vivo. Using pyrazinone analogs and aliphatic amino acids instead of the disulfide bond, we prepared novel type somatostatin analogs including the sequence essential for antitumor activities, Tyr-d-Trp-Lys. These analogs exhibited antiproliferative effect on A431 tumor cells.",
author = "Anna Miyazaki and Toshio Yokoi and Yoshifumi Tachibana and Riyo Enomoto and Eibai Lee and Gyongyi Bokonyi and G. K{\'e}ri and Yuko Tsuda and Yoshio Okada",
year = "2004",
month = "8",
day = "9",
doi = "10.1016/j.tetlet.2004.06.105",
language = "English",
volume = "45",
pages = "6323--6327",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "33",

}

TY - JOUR

T1 - Design and synthesis of novel type somatostatin analogs with antiproliferative activities on A431 tumor cells

AU - Miyazaki, Anna

AU - Yokoi, Toshio

AU - Tachibana, Yoshifumi

AU - Enomoto, Riyo

AU - Lee, Eibai

AU - Bokonyi, Gyongyi

AU - Kéri, G.

AU - Tsuda, Yuko

AU - Okada, Yoshio

PY - 2004/8/9

Y1 - 2004/8/9

N2 - It was reported that the somatostatin analog TT-232, d-Phe-c(Cys-Tyr-d-Trp- Lys-Cys)-Thr-NH 2, exhibited a highly potent antitumor activity in vitro and in vivo. Using pyrazinone analogs and aliphatic amino acids instead of the disulfide bond, we prepared novel type somatostatin analogs including the sequence essential for antitumor activities, Tyr-d-Trp-Lys. These analogs exhibited antiproliferative effect on A431 tumor cells.

AB - It was reported that the somatostatin analog TT-232, d-Phe-c(Cys-Tyr-d-Trp- Lys-Cys)-Thr-NH 2, exhibited a highly potent antitumor activity in vitro and in vivo. Using pyrazinone analogs and aliphatic amino acids instead of the disulfide bond, we prepared novel type somatostatin analogs including the sequence essential for antitumor activities, Tyr-d-Trp-Lys. These analogs exhibited antiproliferative effect on A431 tumor cells.

UR - http://www.scopus.com/inward/record.url?scp=3242758936&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3242758936&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2004.06.105

DO - 10.1016/j.tetlet.2004.06.105

M3 - Article

AN - SCOPUS:3242758936

VL - 45

SP - 6323

EP - 6327

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 33

ER -