Design and process development of a photonic crystal polymer biosensor for point of care diagnostics

F. Dortu, H. Egger, K. Kolari, T. Haatainen, P. Furjes, Z. Fekete, D. Bernier, G. Sharp, B. Lahiri, S. Kurunczi, J. C. Sanchez, N. Turck, P. Petrik, D. Patko, R. Horvath, S. Eidenb, T. Aalto, S. Watts, N. P. Johnson, R. M. De La RuefD. Giannonea

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

In this work, we report advances in the fabrication and anticipated performance of a polymer biosensor photonic chip developed in the European Union project P3SENS (FP7-ICT4-248304). Due to the low cost requirements of point-of-care applications, the photonic chip is fabricated from nanocomposite polymeric materials, using highly scalable nano-imprint-lithography (NIL). A suitable microfluidic structure transporting the analyte solutions to the sensor area is also fabricated in polymer and adequately bonded to the photonic chip. We first discuss the design and the simulated performance of a high-Q resonant cavity photonic crystal sensor made of a high refractive index polyimide core waveguide on a low index polymer cladding. We then report the advances in doped and undoped polymer thin film processing and characterization for fabricating the photonic sensor chip. Finally the development of the microfluidic chip is presented in details, including the characterisation of the fluidic behaviour, the technological and material aspects of the 3D polymer structuring and the stable adhesion strategies for bonding the fluidic and the photonic chips, with regards to the constraints imposed by the bioreceptors supposedly already present on the sensors.

Original languageEnglish
Title of host publicationClinical and Biomedical Spectroscopy and Imaging II
DOIs
Publication statusPublished - Jul 25 2011
EventClinical and Biomedical Spectroscopy and Imaging II - Munich, Germany
Duration: May 24 2011May 26 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8087
ISSN (Print)1605-7422

Other

OtherClinical and Biomedical Spectroscopy and Imaging II
CountryGermany
CityMunich
Period5/24/115/26/11

Keywords

  • Biosensor
  • Lab-on-a-chip
  • Nanocomposites
  • Nanoimprint lithography
  • Photonic crystal
  • Point-of-care diagnostics
  • Polyimide
  • Polymer

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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    Dortu, F., Egger, H., Kolari, K., Haatainen, T., Furjes, P., Fekete, Z., Bernier, D., Sharp, G., Lahiri, B., Kurunczi, S., Sanchez, J. C., Turck, N., Petrik, P., Patko, D., Horvath, R., Eidenb, S., Aalto, T., Watts, S., Johnson, N. P., ... Giannonea, D. (2011). Design and process development of a photonic crystal polymer biosensor for point of care diagnostics. In Clinical and Biomedical Spectroscopy and Imaging II [80870D] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8087). https://doi.org/10.1117/12.889420