Dermatitis Herpetiformis

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Dermatitis herpetiformis (DH) is a chronic, polymorphic, blistering, and pruritic skin disease that develops mostly in patients with a latent gluten-sensitive enteropathy (GSE) called celiac disease. DH patients usually present with skin manifestations only and are not aware of the underlying gluten sensitivity. Perilesional granular IgA deposition at the uppermost papillary layer and lesional neutrophilic accumulation with subepidermal blister formation together prove the diagnosis. Almost all DH patients have circulating gluten-induced transglutaminase 2 (TG2) or endomysium antibodies characteristic for GSE, but they also have anti-TG3 IgA antibodies present only in some celiac patients. Associated autoimmunities, endocrinological, neurological, gastrointestinal pathologies need a careful multidisciplinary follow-up. Family screening for gluten sensitivity by IgA TG2 antibodies or exceptionally by the characteristic HLA background verification is suggested.

Original languageEnglish
Title of host publicationBlistering Diseases: Clinical Features, Pathogenesis, Treatment
PublisherSpringer Berlin Heidelberg
Pages441-447
Number of pages7
ISBN (Print)9783662456989, 9783662456972
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

Dermatitis Herpetiformis
Glutens
Celiac Disease
Immunoglobulin A
Antibodies
Skin Manifestations
Blister
Autoimmunity
Skin Diseases
Abdomen
Pathology
transglutaminase 2

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kárpáti, S. (2015). Dermatitis Herpetiformis. In Blistering Diseases: Clinical Features, Pathogenesis, Treatment (pp. 441-447). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-662-45698-9_44

Dermatitis Herpetiformis. / Kárpáti, S.

Blistering Diseases: Clinical Features, Pathogenesis, Treatment. Springer Berlin Heidelberg, 2015. p. 441-447.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kárpáti, S 2015, Dermatitis Herpetiformis. in Blistering Diseases: Clinical Features, Pathogenesis, Treatment. Springer Berlin Heidelberg, pp. 441-447. https://doi.org/10.1007/978-3-662-45698-9_44
Kárpáti S. Dermatitis Herpetiformis. In Blistering Diseases: Clinical Features, Pathogenesis, Treatment. Springer Berlin Heidelberg. 2015. p. 441-447 https://doi.org/10.1007/978-3-662-45698-9_44
Kárpáti, S. / Dermatitis Herpetiformis. Blistering Diseases: Clinical Features, Pathogenesis, Treatment. Springer Berlin Heidelberg, 2015. pp. 441-447
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