Deranged expression of the E-cadherin/β-catenin complex and the epidermal growth factor receptor in the clinical evolution and progression of oral squamous cell carcinomas

Agnes Bánkfalvi, Melanie Kraßort, András Végh, E. Felszeghy, Jozsef Piffkó

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Background: Deranged expression and function of the E-cadherin/β-catenin (E-cad/β-cat) complex and the epidermal growth factor receptor (EGFR) have been implicated in the development and progression of carcinomas. Methods: To estimate the role of these molecules in oral cancer, we investigated 75 primary oral squamous cell carcinomas (OSCCs) with adjacent normal and/or dysplastic mucosa, 30 paired metastases and 12 recurrences by immunohistochemistry. Results: All three molecules were constitutionally expressed in the basal/parabasal layers of tumour adjacent 'normal' epithelium, in contrast to a significant increase of EGFR and heterogeneous expression of E-cad/β-cat in dysplasia. In OSCCs, overexpression of EGFR correlated significantly with lower tumour grade and poor prognosis, loss of E-cad was a significant marker for shortened survival, reduced β-cat staining was a predictive marker for lymph node metastasis. Conclusions: There is a perturbance in intercellular adhesion molecules and EGFR expression/function in oral cancer with major clinical impact. E-cad and β-cat seem to inhibit EGFR to enhance the progression of OSCCs.

Original languageEnglish
Pages (from-to)450-457
Number of pages8
JournalJournal of Oral Pathology and Medicine
Volume31
Issue number8
DOIs
Publication statusPublished - Sep 2002

Fingerprint

Catenins
Cadherins
Epidermal Growth Factor Receptor
Squamous Cell Carcinoma
Mouth Neoplasms
Cats
Neoplasm Metastasis
Cell Adhesion Molecules
Neoplasms
Mucous Membrane
Epithelium
Lymph Nodes
Immunohistochemistry
Staining and Labeling
Carcinoma
Recurrence

Keywords

  • β-catenin
  • E-cadherin
  • EGFR
  • Immunohistochemistry
  • Metastasis
  • Oral cancer
  • Prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Pathology and Forensic Medicine
  • Dentistry(all)

Cite this

Deranged expression of the E-cadherin/β-catenin complex and the epidermal growth factor receptor in the clinical evolution and progression of oral squamous cell carcinomas. / Bánkfalvi, Agnes; Kraßort, Melanie; Végh, András; Felszeghy, E.; Piffkó, Jozsef.

In: Journal of Oral Pathology and Medicine, Vol. 31, No. 8, 09.2002, p. 450-457.

Research output: Contribution to journalArticle

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