Deramciclane inhibits N-methyl-D-aspartate receptor function

Ilona Kovács, E. Szárics, Nina Skuban, J. Kardos

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Effects of the novel anxiolytic drug deramciclane on excitatory amino acid release and transmembrane Ca2+ ion flux processes were compared in rat cerebrocortical homogenates containing resealed plasmalemma fragments and nerve endings. Deramciclane (10 μM) significantly inhibited [3H]D-aspartate release and transmembrane Ca2+ flux to N-methyl-D-aspartate in the absence of Mg2+. By contrast, inhibition of [3H]D-aspartate release and transmembrane Ca2+ flux evoked by 0.1 mM (S)-α-amino-3-hydroxy-5-methyl-4-isoxazole propionate in the presence of Mg2+ and 10 μM cyclothiazide by 10 μM deramciclane was not significant. In the presence of N-methyl-D-aspartate receptor antagonists, deramciclane (10 μM) did not inhibit [3H]D-aspartate release to N-methyl-D-aspartate. These results suggest an involvement of the inhibition of a presynaptic N-methyl-D-aspartate receptor in the anxiolytic properties of deramciclane. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalBrain Research Bulletin
Volume52
Issue number1
DOIs
Publication statusPublished - May 1 2000

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N-Methyl-D-Aspartate Receptors
D-Aspartic Acid
Anti-Anxiety Agents
N-Methylaspartate
Isoxazoles
Excitatory Amino Acids
Nerve Endings
Propionates
deramciclane
Ions
Pharmaceutical Preparations

Keywords

  • [H]D-aspartate release
  • Ca influx
  • Rat cerebral cortex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Deramciclane inhibits N-methyl-D-aspartate receptor function. / Kovács, Ilona; Szárics, E.; Skuban, Nina; Kardos, J.

In: Brain Research Bulletin, Vol. 52, No. 1, 01.05.2000, p. 39-44.

Research output: Contribution to journalArticle

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