Depressed baroreflex sensitivity in patients with Alzheimer's and Parkinson's disease

Tamás Szili-Török, János Kálmán, Dora Paprika, György Dibó, Zsuzsanna Rózsa, László Rudas

Research output: Contribution to journalArticle

54 Citations (Scopus)


Parkinson's disease (PD) and Alzheimer's dementia (AD) are often associated with an autonomic neuropathy. The extent of autonomic involvement, however is poorly defined and unpredic table. In order to assess the autonomic cardiovascular regulation baroreflex sensitivity (BRS) was determined non-invasively in 23 patients (age: 65 ± 9.3 years) with PD and 24 patients with AD (age: 72.3 ± 7.2 years). The results were compared with those on 22 healthy age- and sex-matched volunteers. Patients with PD and AD exhibited marked abnormalities in cardiovascular autonomic reflex regulation showed by markedly depressed BRS. The possible predictive value of centrally based depression of baroreflex sensitivity necessitates further studies.

Original languageEnglish
Pages (from-to)435-438
Number of pages4
JournalNeurobiology of Aging
Issue number3
Publication statusPublished - Jun 18 2001


  • Alzheimer's dementia
  • Baroreflex sensitivity
  • Parkinson's disease

ASJC Scopus subject areas

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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