(-)Deprenyl - the MAO inhibitor without the 'cheese effect'

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Monoamine oxidase (MAO) inhibitors are potentially important drugs, especially in the treatment of psychiatric disorders. However, non-specific MAO inhibitors block the action of the MAO which are involved in detoxifying various amines derived from various foods, especially cheese, allowing these amines to exert a hypertensive reaction (the so-called 'cheese effect'). This has limited the use of MAO inhibitors as therapeutic agents. However, the discovery of two types of MAO, and the development of (-)deprenyl, the first highly potent, irreversible MAO inhibitor without the 'cheese effect' may change this situation.

Original languageEnglish
Pages (from-to)111-113
Number of pages3
JournalTrends in Neurosciences
Volume2
Issue numberC
DOIs
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Neuroscience(all)

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