(-)-deprenyl a selective mao 'B' inhibitor increases [3H]imipramine binding and decreases β-adrenergic receptor function

Gabriella Zsilla, Maria L. Barbaccia, Ottavio Gandolfi, Joseph Knoll, Erminio Costa

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

In rats, a selective inhibition for 3 weeks of monoamineoxydase (MAO) type B elicited by daily doses of pargyline (2.5 μmol/kg) or (-)-deprenyl (1 μmol/kg) attenuated the NE dependent stimulation of cortical adenylate cyclase and reduced the number of brain recognition sites for β-adrenergic receptor ligands. Similar actions were not elicited by a comparable dose regimen of (+)-amphetamine. Hence the inhibition of MAO B mimicks responses that are typically elicited by antidepressants. The molecular nature of the mechanisms involved cannot be understood, however, these mechanisms may not be identical for pargyline and (-)-deprenyl because this drug but not pargyline increased the number of [3H]imipramine recognition sites. Even high daily doses of pargyline (100 μmol/kg, for 3 weeks) failed to change [3H]imipramine binding though they still down regulated β-adrenergic recognition sites, the NE stimulation of adenylate cyclase and the Bmax of [3H]mianserin and [3H]spiroperidol binding.

Original languageEnglish
Pages (from-to)111-117
Number of pages7
JournalEuropean Journal of Pharmacology
Volume89
Issue number1-2
DOIs
Publication statusPublished - Apr 22 1983

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Keywords

  • 5HT receptors
  • Adenylate cyclase
  • Deprenyl
  • Imipramine
  • MAO B
  • NE
  • β-Adrenergic receptors

ASJC Scopus subject areas

  • Pharmacology

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