Dephosphorylation of tau protein from Alzheimer's disease patients

Kornélia Szücs, Maria D. Ledesma, Viktor Dombrádi, Pál Gergely, Jesús Avila, Peter Friedrich

Research output: Contribution to journalArticle

9 Citations (Scopus)


Tau protein-prepared post-mortem from brains of Alzheimer's disease patients was treated with protein phosphatase 1 catalytic subunit, 2A catalytic subunit, and 2B (calcineurin). Dephosphorylation was monitored by immunoblotting with two monoclonal antibodies. TAU-1 and SMI31, which recognize in tau the dephospho- and phospho-states, respectively, of proline-directed protein kinase phosphorylation sites. Out of the three enzymes tested, protein phosphatase 2A was only effective in dephosphorylating tau at these Alzheimer-type epitopes.

Original languageEnglish
Pages (from-to)175-178
Number of pages4
JournalNeuroscience Letters
Issue number1-2
Publication statusPublished - Jan 3 1994


  • Alzheimer's disease
  • Microtubule-associated protein
  • Proline-directed protein kinase
  • Protein phosphatase 2A
  • Tau protein

ASJC Scopus subject areas

  • Neuroscience(all)

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