Dephosphorylation of tau protein from Alzheimer's disease patients

Kornélia Szücs, Maria D. Ledesma, V. Dombrádi, P. Gergely, Jesús Avila, P. Friedrich

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Tau protein-prepared post-mortem from brains of Alzheimer's disease patients was treated with protein phosphatase 1 catalytic subunit, 2A catalytic subunit, and 2B (calcineurin). Dephosphorylation was monitored by immunoblotting with two monoclonal antibodies. TAU-1 and SMI31, which recognize in tau the dephospho- and phospho-states, respectively, of proline-directed protein kinase phosphorylation sites. Out of the three enzymes tested, protein phosphatase 2A was only effective in dephosphorylating tau at these Alzheimer-type epitopes.

Original languageEnglish
Pages (from-to)175-178
Number of pages4
JournalNeuroscience Letters
Volume165
Issue number1-2
DOIs
Publication statusPublished - Jan 3 1994

Fingerprint

Proline-Directed Protein Kinases
Protein Phosphatase 1
Protein Phosphatase 2
tau Proteins
Calcineurin
Brain Diseases
Immunoblotting
Epitopes
Catalytic Domain
Alzheimer Disease
Monoclonal Antibodies
Phosphorylation
Enzymes

Keywords

  • Alzheimer's disease
  • Microtubule-associated protein
  • Proline-directed protein kinase
  • Protein phosphatase 2A
  • Tau protein

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dephosphorylation of tau protein from Alzheimer's disease patients. / Szücs, Kornélia; Ledesma, Maria D.; Dombrádi, V.; Gergely, P.; Avila, Jesús; Friedrich, P.

In: Neuroscience Letters, Vol. 165, No. 1-2, 03.01.1994, p. 175-178.

Research output: Contribution to journalArticle

Szücs, Kornélia ; Ledesma, Maria D. ; Dombrádi, V. ; Gergely, P. ; Avila, Jesús ; Friedrich, P. / Dephosphorylation of tau protein from Alzheimer's disease patients. In: Neuroscience Letters. 1994 ; Vol. 165, No. 1-2. pp. 175-178.
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