Deoxycytidine is salvaged not only into dna but also into phospholipid precursors

Tatjana Spasokukotskaja, Giannis Spyrou, M. Staub

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Deoxycytidine metabolism was investigated in light density human tonsillar lymphocytes using 5-3H-deoxycytidine as extracellular precursor. A significant portion of the deoxycytidine (more than 50% of ethanol soluble pool) was found to incorporate into dCDP-choline and dCDP-ethanolamine beside the well-known pathway i.e incorporation into DNA in form of dCMP and dTMP. Hydroxyurea increased the labeling of the deoxyliponucleotides from 5-3H-deoxycytidine in spite of its inhibition of DNA synthesis.

Original languageEnglish
Pages (from-to)923-929
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume155
Issue number2
DOIs
Publication statusPublished - Sep 15 1988

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Deoxycytidine
Phospholipids
Ethanolamine
Hydroxyurea
Lymphocytes
DNA
Choline
Metabolism
Labeling
Ethanol
Light
2'-deoxycytidine diphosphate

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Deoxycytidine is salvaged not only into dna but also into phospholipid precursors. / Spasokukotskaja, Tatjana; Spyrou, Giannis; Staub, M.

In: Biochemical and Biophysical Research Communications, Vol. 155, No. 2, 15.09.1988, p. 923-929.

Research output: Contribution to journalArticle

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