Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups

Myositis Genetics Consortium

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Objectives The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare autoimmune diseases characterised by muscle weakness and extramuscular manifestations such as skin rashes and interstitial lung disease. We genotyped 2566 IIM cases of Caucasian descent using the Immunochip; a custom array covering 186 established autoimmune susceptibility loci. The cohort was predominantly comprised of patients with dermatomyositis (DM, n=879), juvenile DM (JDM, n=481), polymyositis (PM, n=931) and inclusion body myositis (n=252) collected from 14 countries through the Myositis Genetics Consortium. Results The human leucocyte antigen (HLA) and PTPN22 regions reached genome-wide significance (p

Original languageEnglish
JournalAnnals of the Rheumatic Diseases
DOIs
Publication statusAccepted/In press - Sep 11 2015

Fingerprint

Pulmonary diseases
Myositis
HLA Antigens
Muscle
Skin
Genes
Alleles
Inclusion Body Myositis
Polymyositis
Dermatomyositis
Interstitial Lung Diseases
Muscle Weakness
Rare Diseases
Exanthema
Autoimmune Diseases
Genome
Genetic Background
Genetics

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy

Cite this

@article{2e6947efaf3743aa8da74e6ae3f1bb55,
title = "Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups",
abstract = "Objectives The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare autoimmune diseases characterised by muscle weakness and extramuscular manifestations such as skin rashes and interstitial lung disease. We genotyped 2566 IIM cases of Caucasian descent using the Immunochip; a custom array covering 186 established autoimmune susceptibility loci. The cohort was predominantly comprised of patients with dermatomyositis (DM, n=879), juvenile DM (JDM, n=481), polymyositis (PM, n=931) and inclusion body myositis (n=252) collected from 14 countries through the Myositis Genetics Consortium. Results The human leucocyte antigen (HLA) and PTPN22 regions reached genome-wide significance (p",
author = "{Myositis Genetics Consortium} and Simon Rothwell and Cooper, {Robert G.} and Lundberg, {Ingrid E.} and Miller, {Frederick W.} and Gregersen, {Peter K.} and John Bowes and Jiri Vencovsky and K. Dank{\'o} and Vidya Limaye and O'Callaghan, {Albert Selva} and Hanna, {Michael G.} and Machado, {Pedro M.} and Pachman, {Lauren M.} and Reed, {Ann M.} and Rider, {Lisa G.} and Joanna Cobb and Hazel Platt and {\O}yvind Molberg and Olivier Benveniste and Pernille Mathiesen and Timothy Radstake and Andrea Doria and Bleecker, {Jan De} and Paepe, {Boel De} and Britta Maurer and Ollier, {William E.} and Leonid Padyukov and O'Hanlon, {Terrance P.} and Annette Lee and Amos, {Christopher I.} and Christian Gieger and Thomas Meitinger and Juliane Winkelmann and Wedderburn, {Lucy R.} and Hector Chinoy and Lamb, {Janine A.} and Christopher Denton and Herman Mann and David Hilton-Jones and Patrick Kiely and Plotz, {Paul H.} and Mark Gourley and Kelly Rouster-Stevens and Huber, {Adam M.} and Galina Marder and Mazen Dimachkie",
year = "2015",
month = "9",
day = "11",
doi = "10.1136/annrheumdis-2015-208119",
language = "English",
journal = "Annals of the Rheumatic Diseases",
issn = "0003-4967",
publisher = "BMJ Publishing Group",

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TY - JOUR

T1 - Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups

AU - Myositis Genetics Consortium

AU - Rothwell, Simon

AU - Cooper, Robert G.

AU - Lundberg, Ingrid E.

AU - Miller, Frederick W.

AU - Gregersen, Peter K.

AU - Bowes, John

AU - Vencovsky, Jiri

AU - Dankó, K.

AU - Limaye, Vidya

AU - O'Callaghan, Albert Selva

AU - Hanna, Michael G.

AU - Machado, Pedro M.

AU - Pachman, Lauren M.

AU - Reed, Ann M.

AU - Rider, Lisa G.

AU - Cobb, Joanna

AU - Platt, Hazel

AU - Molberg, Øyvind

AU - Benveniste, Olivier

AU - Mathiesen, Pernille

AU - Radstake, Timothy

AU - Doria, Andrea

AU - Bleecker, Jan De

AU - Paepe, Boel De

AU - Maurer, Britta

AU - Ollier, William E.

AU - Padyukov, Leonid

AU - O'Hanlon, Terrance P.

AU - Lee, Annette

AU - Amos, Christopher I.

AU - Gieger, Christian

AU - Meitinger, Thomas

AU - Winkelmann, Juliane

AU - Wedderburn, Lucy R.

AU - Chinoy, Hector

AU - Lamb, Janine A.

AU - Denton, Christopher

AU - Mann, Herman

AU - Hilton-Jones, David

AU - Kiely, Patrick

AU - Plotz, Paul H.

AU - Gourley, Mark

AU - Rouster-Stevens, Kelly

AU - Huber, Adam M.

AU - Marder, Galina

AU - Dimachkie, Mazen

PY - 2015/9/11

Y1 - 2015/9/11

N2 - Objectives The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare autoimmune diseases characterised by muscle weakness and extramuscular manifestations such as skin rashes and interstitial lung disease. We genotyped 2566 IIM cases of Caucasian descent using the Immunochip; a custom array covering 186 established autoimmune susceptibility loci. The cohort was predominantly comprised of patients with dermatomyositis (DM, n=879), juvenile DM (JDM, n=481), polymyositis (PM, n=931) and inclusion body myositis (n=252) collected from 14 countries through the Myositis Genetics Consortium. Results The human leucocyte antigen (HLA) and PTPN22 regions reached genome-wide significance (p

AB - Objectives The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare autoimmune diseases characterised by muscle weakness and extramuscular manifestations such as skin rashes and interstitial lung disease. We genotyped 2566 IIM cases of Caucasian descent using the Immunochip; a custom array covering 186 established autoimmune susceptibility loci. The cohort was predominantly comprised of patients with dermatomyositis (DM, n=879), juvenile DM (JDM, n=481), polymyositis (PM, n=931) and inclusion body myositis (n=252) collected from 14 countries through the Myositis Genetics Consortium. Results The human leucocyte antigen (HLA) and PTPN22 regions reached genome-wide significance (p

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U2 - 10.1136/annrheumdis-2015-208119

DO - 10.1136/annrheumdis-2015-208119

M3 - Article

C2 - 26362759

AN - SCOPUS:84941695475

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

ER -