Dendritic Spikes Induce Ripples in Parvalbumin Interneurons during Hippocampal Sharp Waves

Balázs Chiovini, GergelyF Turi, Gergely Katona, Attila Kaszás, Dénes Pálfi, Pál Maák, Gergely Szalay, MátyásForián Szabó, Gábor Szabó, Zoltán Szadai, Szabolcs Káli, B. Rózsa

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Sharp-wave ripples are transient oscillatory events in the hippocampus that are associated with the reactivation of neuronal ensembles within specific circuits during memory formation. Fast-spiking, parvalbumin-expressing interneurons (FS-PV INs) are thought to provide fast integration in these oscillatory circuits by suppressing regenerative activity in their dendrites. Here, using fast 3D two-photon imaging and a caged glutamate, we challenge this classical view by demonstrating that FS-PV IN dendrites can generate propagating Ca2+ spikes during sharp-wave ripples. The spikes originate from dendritic hot spots and are mediated dominantly by L-type Ca2+ channels. Notably, Ca2+ spikes were associated with intrinsically generated membrane potential oscillations. These oscillations required the activation of voltage-gated Na+ channels, had the same frequency as the field potential oscillations associated with sharp-wave ripples, and controlled the phase of action potentials. Furthermore, our results demonstrate that the smallest functional unit that can generate ripple-frequency oscillations is a segment of a dendrite.

Original languageEnglish
Pages (from-to)908-924
Number of pages17
JournalNeuron
Volume82
Issue number4
DOIs
Publication statusPublished - May 21 2014

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Parvalbumins
Interneurons
Dendrites
Photons
Membrane Potentials
Action Potentials
Glutamic Acid
Hippocampus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dendritic Spikes Induce Ripples in Parvalbumin Interneurons during Hippocampal Sharp Waves. / Chiovini, Balázs; Turi, GergelyF; Katona, Gergely; Kaszás, Attila; Pálfi, Dénes; Maák, Pál; Szalay, Gergely; Szabó, MátyásForián; Szabó, Gábor; Szadai, Zoltán; Káli, Szabolcs; Rózsa, B.

In: Neuron, Vol. 82, No. 4, 21.05.2014, p. 908-924.

Research output: Contribution to journalArticle

Chiovini, B, Turi, G, Katona, G, Kaszás, A, Pálfi, D, Maák, P, Szalay, G, Szabó, M, Szabó, G, Szadai, Z, Káli, S & Rózsa, B 2014, 'Dendritic Spikes Induce Ripples in Parvalbumin Interneurons during Hippocampal Sharp Waves', Neuron, vol. 82, no. 4, pp. 908-924. https://doi.org/10.1016/j.neuron.2014.04.004
Chiovini B, Turi G, Katona G, Kaszás A, Pálfi D, Maák P et al. Dendritic Spikes Induce Ripples in Parvalbumin Interneurons during Hippocampal Sharp Waves. Neuron. 2014 May 21;82(4):908-924. https://doi.org/10.1016/j.neuron.2014.04.004
Chiovini, Balázs ; Turi, GergelyF ; Katona, Gergely ; Kaszás, Attila ; Pálfi, Dénes ; Maák, Pál ; Szalay, Gergely ; Szabó, MátyásForián ; Szabó, Gábor ; Szadai, Zoltán ; Káli, Szabolcs ; Rózsa, B. / Dendritic Spikes Induce Ripples in Parvalbumin Interneurons during Hippocampal Sharp Waves. In: Neuron. 2014 ; Vol. 82, No. 4. pp. 908-924.
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