Demonstration of stereoselective disposition of warfarin enantiomers by whole-body autoradiography

I. Szinai, M. Simonyi, I. Fitos, Zs Tegyey, A. Magyar

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The oral anticoagulant warfarin and its14C-labelled derivative are commercially available in racemic forms. Two methods for the chromatographic resolution of the radiolabel were used to investigate the distribution of radioactivity of individual enantiomers in the rat by whole-body autoradiography. Computer-assisted quantification of autoradiograms indicated the average disappearance of levo-warfarin and its metabolites to be substantially slower than that of dextro-warfarin and its metabolites from the following organs: liver, pancreas, kidney, lung, blood, intestines.

Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalEuropean Journal of Drug Metabolism and Pharmacokinetics
Volume15
Issue number2
DOIs
Publication statusPublished - Apr 1 1990

Keywords

  • Resolution of [C]rac-warfarin
  • computer-assisted quantification of autoradiograms
  • stereoselective whole-body autoradiography

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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