Demonstration of EBNA (Epstein-Barr virus nuclear antigen) antibodies of different immunoglobulin classes.

J. Czeglédy, L. Gergely, L. Váczi, A. Szalka

Research output: Contribution to journalArticle

Abstract

Anit-EBNA IgM, a previously unknown antibody, was detected by the antihuman globulin anticomplement immunofluorescence (ACIF) method in serum samples from acute infectious mononucleosis (IM) of Epstein-Barr virus (EBV) origin. The antibody disappears from the serum in some weeks during convalescence. It was absent in anti-EBV=positive sera of healthy donors and in serum samples taken from patients with IM caused by cytomegalo-virus. The antibody appears simultaneously with anti-EBV IgmM and, reaching a lower titre than the latter, its titre curve runs parallel with the anti-EBV IgM curve. Since in acute EBV infections, anti-EBNA IgM always appeared, its presence may serve as an additional evidence of the acuteness of EBV infection. In EBV-seropositive healthy subjects, the bulk of antibodies belongs to the IgG class, non-complement-fixing IgA antibodies occur only sporadically.

Original languageEnglish
Pages (from-to)237-243
Number of pages7
JournalActa Microbiologica Academiae Scientiarum Hungaricae
Volume25
Issue number4
Publication statusPublished - 1978

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Epstein-Barr Virus Nuclear Antigens
Immunoglobulin Isotypes
Human Herpesvirus 4
Antibodies
Immunoglobulin M
Infectious Mononucleosis
Epstein-Barr Virus Infections
Serum
Globulins
Immunoglobulin A
Fluorescent Antibody Technique
Healthy Volunteers
Immunoglobulin G
Tissue Donors
Viruses

ASJC Scopus subject areas

  • Medicine(all)

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Demonstration of EBNA (Epstein-Barr virus nuclear antigen) antibodies of different immunoglobulin classes. / Czeglédy, J.; Gergely, L.; Váczi, L.; Szalka, A.

In: Acta Microbiologica Academiae Scientiarum Hungaricae, Vol. 25, No. 4, 1978, p. 237-243.

Research output: Contribution to journalArticle

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