Extracts from bovine brain show significant diazepam displacing activity in receptor binding assay. The proteinase sensitive component of this benzo‐diazepine‐like activity has been resolved into three main fractions by chromatography on a Sephadex G‐75 column. The most active fraction that contains the largest proteins has been further characterized and shown to be a noncompetitive inhibitor of the diazepam binding to synaptic brain membranes.
|Number of pages||4|
|Journal||International journal of peptide and protein research|
|Publication status||Published - Jul 1981|
- benzodiazepine receptors
- endogenous ligand
- modulator protein
ASJC Scopus subject areas