DEMONSTRATION OF AN ENDOGENOUS, HIGHLY POTENT, NONCOMPETITIVE PROTEIN INHIBITOR(S) OF 3H‐DIAZEPAM BINDING IN BOVINE BRAIN

ÁGNES KENESSEY, TIBOR LÁNG, LÁSZLÓ GRÁF

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Abstract

Extracts from bovine brain show significant diazepam displacing activity in receptor binding assay. The proteinase sensitive component of this benzo‐diazepine‐like activity has been resolved into three main fractions by chromatography on a Sephadex G‐75 column. The most active fraction that contains the largest proteins has been further characterized and shown to be a noncompetitive inhibitor of the diazepam binding to synaptic brain membranes.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalInternational journal of peptide and protein research
Volume18
Issue number1
DOIs
Publication statusPublished - Jul 1981

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Keywords

  • benzodiazepine receptors
  • endogenous ligand
  • modulator protein

ASJC Scopus subject areas

  • Biochemistry

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