Téveszme, hiedelem és meggyozodés: a normalitás kérdése pszichológiai, élettani és molekuláris biológiai szemszögbol

Translated title of the contribution: Delusion, belief, and conviction: The question of normality from the viewpoint of psychology, physiology, and molecular biology

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

According to the classic definition, delusion is a fixed false belief that is incompatible with reality and cannot be modified and corrected by persuasion and facts. More recently, it is often considered as a phenomenon similar to everyday belief formation, in which sensory and reasoning biases play an important role. Biased processing of social signals, unusual experiences, and search for meaning lead to beliefs via early jumping to conclusions, attributional biases, and mentalization. These processes may be modulated by social context and may turn into a self-reinforcing circle. In this paper, I present data demonstrating the normal distribution of delusion-like phenomena in the general population, similarly to their physiological and molecular markers (habituation of autonomic arousal, activation of the AKT intracellular messenger system). From a neurochemical point of view, dopamine has a positive effect ameliorating apathy and some cognitive deficits in neurological disorders, but its receptor agonists may induce psychotic-like phenomena, including overvalued ideas in patients with Parkinson's disease. This can be explained by increased aberrant salience in simple conditioning paradigms. The most important challenge for future research is to identify the disease-predictive effect of these subclinical signs and biological markers.

Original languageHungarian
Pages (from-to)295-315
Number of pages21
JournalMagyar Pszichologiai Szemle
Volume67
Issue number2
DOIs
Publication statusPublished - Jun 1 2012

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Delusions
Molecular Biology
Psychology
Persuasive Communication
Apathy
Normal Distribution
Arousal
Nervous System Diseases
Parkinson Disease
Dopamine
Biomarkers
Population

ASJC Scopus subject areas

  • Psychology(all)

Cite this

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title = "T{\'e}veszme, hiedelem {\'e}s meggyozod{\'e}s: a normalit{\'a}s k{\'e}rd{\'e}se pszichol{\'o}giai, {\'e}lettani {\'e}s molekul{\'a}ris biol{\'o}giai szemsz{\"o}gbol",
abstract = "According to the classic definition, delusion is a fixed false belief that is incompatible with reality and cannot be modified and corrected by persuasion and facts. More recently, it is often considered as a phenomenon similar to everyday belief formation, in which sensory and reasoning biases play an important role. Biased processing of social signals, unusual experiences, and search for meaning lead to beliefs via early jumping to conclusions, attributional biases, and mentalization. These processes may be modulated by social context and may turn into a self-reinforcing circle. In this paper, I present data demonstrating the normal distribution of delusion-like phenomena in the general population, similarly to their physiological and molecular markers (habituation of autonomic arousal, activation of the AKT intracellular messenger system). From a neurochemical point of view, dopamine has a positive effect ameliorating apathy and some cognitive deficits in neurological disorders, but its receptor agonists may induce psychotic-like phenomena, including overvalued ideas in patients with Parkinson's disease. This can be explained by increased aberrant salience in simple conditioning paradigms. The most important challenge for future research is to identify the disease-predictive effect of these subclinical signs and biological markers.",
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