Delayed release matrix pellet preparation containing an alkalizing pore-former agent

Elnazeer I. Hamedelniel, János Bajdik, Tamás Sovány, Klára Pintye-Hódi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The aim of this study was to develop a delayed-release matrix pellet containing atenolol as active pharmaceutical ingredient. The matrix additionally contained trisodium phosphate dodecahydrate as alkalizing pore-former agent to enhance the dissolution of the atenolol at pH 6.8. The delayed release was ensured by coating with a gastro-resistant polymer. For this purpose, an acryl EZE MP aqueous dispersion was used, which is suggested in the literature for pellet coating. Before this functional film coating, a protective polymer layer was developed, to prevent direct contact between the alkalizing layer and the acryl EZE. The results of in vitro dissolution tests demonstrated that the double-coated pellet preparation is a delayed-release solid dosage form.

Original languageEnglish
Pages (from-to)1006-1010
Number of pages5
JournalChemical Engineering Research and Design
Volume89
Issue number7
DOIs
Publication statusPublished - Jul 1 2011

Keywords

  • Coating
  • Delayed release
  • Dissolution test
  • Matrix pellet
  • Pore-former agent

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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