Delayed gastric emptying induced by inhibitors of nitric oxide synthase in rats

Victor Plourde, Enrique Quintero, Gabor Suto, Claudia Coimbra, Yvette Taché

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The effect of the nitric oxide (NO) synthase inhibitor, NG-nitro-l-arginine methyl ester, on gastric emptying of a non-nutrient solution was investigated in conscious rats. NG-Monomethyl-l-arginine (10 mg/kg i.v.) and NG-nitro-l-arginine methyl ester (3 or 10 mg/kg i.v.) inhibited the 20-min rate of gastric emptying of liquids by 34%, 69% and 84% respectively, whereas the 0.3 mg/kg of NG-nitro-l-arginine methyl ester or 3 mg/kg of NG-monomethyl-l-arginine had no effect. The inhibitory effect of NG-nitro-l-arginine methyl ester (3 mg/kg) was prevented by l-arginine (300 mg/kg i.v.), but not by d-arginine (300 mg/kg i.v.). NG-Nitro-l-arginine methyl ester (0.3-10 mg/kg) induced a dose-related increase in mean blood pressure up to 161 ± 10 mm Hg. Spontaneous hypertensive rats with a mean blood pressure of 180 ± 5 mm Hg had a gastric emptying rate of 51.9 ± 6.1%. These data indicate that NO synthase inhibitors given i.v. at doses that inhibit NO synthase, delay gastric emptying through mechanisms which are unrelated to changes in arterial blood pressure.

Original languageEnglish
Pages (from-to)125-129
Number of pages5
JournalEuropean Journal of Pharmacology
Volume256
Issue number2
DOIs
Publication statusPublished - Apr 21 1994

Keywords

  • Blood pressure
  • Gastric emptying
  • N-Monomethyl-l-arginine
  • N-Nitro-l-arginine methyl ester
  • Nitric oxide (NO)
  • l-Arginine

ASJC Scopus subject areas

  • Pharmacology

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