Delayed exercise-induced protection against arrhythmias in dogs - Effect of celecoxib

Orsolya Nagy, Ágnes Hajnal, James R. Parratt, Ágnes Végh

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A 20-min period of treadmill exercise in dogs, sufficient to increase heart rate by 90-100 beats min -1, markedly decreases the severity of the life-threatening ventricular arrhythmias that result when, following anaesthesia 24 h later, the left coronary artery is occluded. This protection was unaffected by the administration of the selective cyclooxygenase-2 inhibitor celecoxib (two times 3 mg kg -1 given intravenously). These results show that prostacyclin, derived from cyclooxygenase-2, plays no role in this pronounced delayed cardioprotection.

Original languageEnglish
Pages (from-to)197-199
Number of pages3
JournalEuropean Journal of Pharmacology
Volume499
Issue number1-2
DOIs
Publication statusPublished - Sep 19 2004

Keywords

  • Arrhythmias
  • Celecoxib
  • Delayed preconditioning

ASJC Scopus subject areas

  • Pharmacology

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