Dehydroepiandrosterone sulphate in the diagnosis of osteoporosis.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Several data suggest that adrenal androgens have an important role in the pathogenesis of postmenopausal osteoporosis. To study the possible relationship between bone density and serum levels of dehydroepiandrosterone sulphate (DHEAS) we investigated 105 women (45-69 years). Serum DHEAS level was significantly lower in the osteoporotic group than in the normal one. The serum level of DHEAS decreased significantly with age in both groups. We established a significant positive correlation between DHEAS and bone mineral density of the lumbar spine and femoral neck, and bone mineral content of radius midshaft as well. Since there was no significant difference between the two groups regarding oestrogens, we suggest that DHEAS may have a non-oestrogenic effect on bone. We conclude that serum DHEAS may have a useful indicator of low bone mineral density in peri-and postmenopausal women.

Original languageEnglish
Pages (from-to)139-146
Number of pages8
JournalActa bio-medica de L'Ateneo parmense : organo della Società di medicina e scienze naturali di Parma
Volume66
Issue number3-4
Publication statusPublished - 1995

Fingerprint

Dehydroepiandrosterone Sulfate
Osteoporosis
Bone Density
Serum
Postmenopausal Osteoporosis
Femur Neck
Androgens
Estrogens
Spine
Bone and Bones

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{869e60b9ec9a4665af66b58af3686c53,
title = "Dehydroepiandrosterone sulphate in the diagnosis of osteoporosis.",
abstract = "Several data suggest that adrenal androgens have an important role in the pathogenesis of postmenopausal osteoporosis. To study the possible relationship between bone density and serum levels of dehydroepiandrosterone sulphate (DHEAS) we investigated 105 women (45-69 years). Serum DHEAS level was significantly lower in the osteoporotic group than in the normal one. The serum level of DHEAS decreased significantly with age in both groups. We established a significant positive correlation between DHEAS and bone mineral density of the lumbar spine and femoral neck, and bone mineral content of radius midshaft as well. Since there was no significant difference between the two groups regarding oestrogens, we suggest that DHEAS may have a non-oestrogenic effect on bone. We conclude that serum DHEAS may have a useful indicator of low bone mineral density in peri-and postmenopausal women.",
author = "M. Szab{\'o}",
year = "1995",
language = "English",
volume = "66",
pages = "139--146",
journal = "Acta Biomedica de l'Ateneo Parmense",
issn = "0392-4203",
publisher = "L'Ateneo Parmense",
number = "3-4",

}

TY - JOUR

T1 - Dehydroepiandrosterone sulphate in the diagnosis of osteoporosis.

AU - Szabó, M.

PY - 1995

Y1 - 1995

N2 - Several data suggest that adrenal androgens have an important role in the pathogenesis of postmenopausal osteoporosis. To study the possible relationship between bone density and serum levels of dehydroepiandrosterone sulphate (DHEAS) we investigated 105 women (45-69 years). Serum DHEAS level was significantly lower in the osteoporotic group than in the normal one. The serum level of DHEAS decreased significantly with age in both groups. We established a significant positive correlation between DHEAS and bone mineral density of the lumbar spine and femoral neck, and bone mineral content of radius midshaft as well. Since there was no significant difference between the two groups regarding oestrogens, we suggest that DHEAS may have a non-oestrogenic effect on bone. We conclude that serum DHEAS may have a useful indicator of low bone mineral density in peri-and postmenopausal women.

AB - Several data suggest that adrenal androgens have an important role in the pathogenesis of postmenopausal osteoporosis. To study the possible relationship between bone density and serum levels of dehydroepiandrosterone sulphate (DHEAS) we investigated 105 women (45-69 years). Serum DHEAS level was significantly lower in the osteoporotic group than in the normal one. The serum level of DHEAS decreased significantly with age in both groups. We established a significant positive correlation between DHEAS and bone mineral density of the lumbar spine and femoral neck, and bone mineral content of radius midshaft as well. Since there was no significant difference between the two groups regarding oestrogens, we suggest that DHEAS may have a non-oestrogenic effect on bone. We conclude that serum DHEAS may have a useful indicator of low bone mineral density in peri-and postmenopausal women.

UR - http://www.scopus.com/inward/record.url?scp=0029445941&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029445941&partnerID=8YFLogxK

M3 - Article

VL - 66

SP - 139

EP - 146

JO - Acta Biomedica de l'Ateneo Parmense

JF - Acta Biomedica de l'Ateneo Parmense

SN - 0392-4203

IS - 3-4

ER -