Dehydration decreases plasma level of α-melanocyte stimulating hormone (α-MSH) and attenuates suckling-induced β-endorphin but not ACTH response in lactating rats

G. M. Nagy, M. Vecsernyés, J. Julesz, I. Barna, J. I. Koenig

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Abstract

When lactating rats are exposed to a short term dehydration, anterior lobe (AL) prolactin (PRL) secretion is immediately depressed. Since tuberohypophysial dopaminergic (THDA) neurons are osmosensitive and regulate the secretion of POMC peptides (α-MSH and β-endorphin) form the intermediate lobe (IL) and dopamine is known to be the major physiological regulator of PRL secretion we have investigated the effect of dehydration on plasma levels of α-MSH, ACTH and β-endorphin detected after suckling stimulus in lactating rats. Changes in the hydromineral balance induced by salt loading severely attenuated plasma level of α-MSH. This effect seems to be specific on peptides secreted by melanotropes because neither basal nor suckling-induced ACTH secreted by corticotropes changed during dehydration. Reduction in plasma level of β-endorphin due to 4 h separation was intensified and the suckling-induced response was attenuated in dehydrated mothers. In summary, the simultaneous and resembling changes in the release of α-MSH, β-endorphin and PRL support our assumption that the regulation of AL and IL is closely coupled and THDA system is one of the common hypothalamic pathways.

Original languageEnglish
Pages (from-to)275-284
Number of pages10
JournalNeuroendocrinology Letters
Volume16
Issue number5-6
Publication statusPublished - 1994

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Endorphins
Melanocyte-Stimulating Hormones
Dehydration
Adrenocorticotropic Hormone
Prolactin
Pro-Opiomelanocortin
Peptides
Dopaminergic Neurons
Dopamine
Salts

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

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title = "Dehydration decreases plasma level of α-melanocyte stimulating hormone (α-MSH) and attenuates suckling-induced β-endorphin but not ACTH response in lactating rats",
abstract = "When lactating rats are exposed to a short term dehydration, anterior lobe (AL) prolactin (PRL) secretion is immediately depressed. Since tuberohypophysial dopaminergic (THDA) neurons are osmosensitive and regulate the secretion of POMC peptides (α-MSH and β-endorphin) form the intermediate lobe (IL) and dopamine is known to be the major physiological regulator of PRL secretion we have investigated the effect of dehydration on plasma levels of α-MSH, ACTH and β-endorphin detected after suckling stimulus in lactating rats. Changes in the hydromineral balance induced by salt loading severely attenuated plasma level of α-MSH. This effect seems to be specific on peptides secreted by melanotropes because neither basal nor suckling-induced ACTH secreted by corticotropes changed during dehydration. Reduction in plasma level of β-endorphin due to 4 h separation was intensified and the suckling-induced response was attenuated in dehydrated mothers. In summary, the simultaneous and resembling changes in the release of α-MSH, β-endorphin and PRL support our assumption that the regulation of AL and IL is closely coupled and THDA system is one of the common hypothalamic pathways.",
author = "Nagy, {G. M.} and M. Vecserny{\'e}s and J. Julesz and I. Barna and Koenig, {J. I.}",
year = "1994",
language = "English",
volume = "16",
pages = "275--284",
journal = "Neuroendocrinology Letters",
issn = "0172-780X",
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TY - JOUR

T1 - Dehydration decreases plasma level of α-melanocyte stimulating hormone (α-MSH) and attenuates suckling-induced β-endorphin but not ACTH response in lactating rats

AU - Nagy, G. M.

AU - Vecsernyés, M.

AU - Julesz, J.

AU - Barna, I.

AU - Koenig, J. I.

PY - 1994

Y1 - 1994

N2 - When lactating rats are exposed to a short term dehydration, anterior lobe (AL) prolactin (PRL) secretion is immediately depressed. Since tuberohypophysial dopaminergic (THDA) neurons are osmosensitive and regulate the secretion of POMC peptides (α-MSH and β-endorphin) form the intermediate lobe (IL) and dopamine is known to be the major physiological regulator of PRL secretion we have investigated the effect of dehydration on plasma levels of α-MSH, ACTH and β-endorphin detected after suckling stimulus in lactating rats. Changes in the hydromineral balance induced by salt loading severely attenuated plasma level of α-MSH. This effect seems to be specific on peptides secreted by melanotropes because neither basal nor suckling-induced ACTH secreted by corticotropes changed during dehydration. Reduction in plasma level of β-endorphin due to 4 h separation was intensified and the suckling-induced response was attenuated in dehydrated mothers. In summary, the simultaneous and resembling changes in the release of α-MSH, β-endorphin and PRL support our assumption that the regulation of AL and IL is closely coupled and THDA system is one of the common hypothalamic pathways.

AB - When lactating rats are exposed to a short term dehydration, anterior lobe (AL) prolactin (PRL) secretion is immediately depressed. Since tuberohypophysial dopaminergic (THDA) neurons are osmosensitive and regulate the secretion of POMC peptides (α-MSH and β-endorphin) form the intermediate lobe (IL) and dopamine is known to be the major physiological regulator of PRL secretion we have investigated the effect of dehydration on plasma levels of α-MSH, ACTH and β-endorphin detected after suckling stimulus in lactating rats. Changes in the hydromineral balance induced by salt loading severely attenuated plasma level of α-MSH. This effect seems to be specific on peptides secreted by melanotropes because neither basal nor suckling-induced ACTH secreted by corticotropes changed during dehydration. Reduction in plasma level of β-endorphin due to 4 h separation was intensified and the suckling-induced response was attenuated in dehydrated mothers. In summary, the simultaneous and resembling changes in the release of α-MSH, β-endorphin and PRL support our assumption that the regulation of AL and IL is closely coupled and THDA system is one of the common hypothalamic pathways.

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M3 - Article

VL - 16

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EP - 284

JO - Neuroendocrinology Letters

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