Degrees of freedom effect on fragmentation in tandem mass spectrometry of singly charged supramolecular aggregates of sodium sulfonates

Serena Indelicato, David Bongiorno, Sergio Indelicato, Laszlo Drahos, Vincenzo Turco Liveri, Lilla Turiák, Karoly Vékey, Leopoldo Ceraulo

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The characteristic collision energy (CCE) to obtain 50% fragmentation of positively and negatively single charged noncovalent clusters has been measured. CCE was found to increase linearly with the degrees of freedom (DoF) of the precursor ion, analogously to that observed for synthetic polymers. This suggests that fragmentation behavior (e.g. energy randomization) in covalent molecules and clusters are similar. Analysis of the slope of CCE with molecular size (DoF) indicates that activation energy of fragmentation of these clusters (loss of a monomer unit) is similar to that of the lowest energy fragmentation of protonated leucine-enkephalin. Positively and negatively charged aggregates behave similarly, but the slope of the CCE versus DoF plot is steeper for positive ions, suggesting that these are more stable than their negative counterparts.

Original languageEnglish
Pages (from-to)379-383
Number of pages5
JournalJournal of Mass Spectrometry
Volume48
Issue number3
DOIs
Publication statusPublished - Mar 2013

Keywords

  • Degrees of Freedom effect
  • MS/MS
  • Supramolecular aggregates
  • activation energy
  • fragmentation

ASJC Scopus subject areas

  • Spectroscopy

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