Degradation of glutathione in aspergillus nidulans

Zsolt Spitzmüller, Márton Hajdú, I. Pócsi, T. Emri

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Relative transcriptions of Aspergillus nidulans dug1-3 (orthologes of Saccharomyces cerevisiae DUG-deficient in utilization of glutathione-pathway genes) and ggtA encoding g-glutamyl transpeptidase were studied under conditions inducing glutathione degradation. GgtA was induced in all cases when glutathione levels decreased, but addition of yeast extract, which moderated glutathione degradation, enhanced its induction. Although dug2 showed constitutive transcription, dug1 and dug3 were induced by carbon and nitrogen starvation and yeast extract did not caused significant changes in their relative transcription. The in silico reconstructed DUG pathway of A. nidulans is a promising candidate for cytosolic GSH degradation induced by carbon/nitrogen stress.

Original languageEnglish
Pages (from-to)242-245
Number of pages4
JournalActa Biologica Hungarica
Volume66
Issue number2
DOIs
Publication statusPublished - Jun 1 2015

Fingerprint

Aspergillus nidulans
Aspergillus
Glutathione
Transcription
Yeast
Degradation
degradation
yeast
Nitrogen
Carbon
Yeasts
nitrogen
carbon
starvation
gamma-Glutamyltransferase
Starvation
Computer Simulation
Saccharomyces cerevisiae
gene
Genes

Keywords

  • Aspergillus nidulans
  • Carbon stress
  • DUG pathway
  • Glutathione degradation
  • γ-glutamyl transpeptidase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Neurology
  • Medicine(all)

Cite this

Degradation of glutathione in aspergillus nidulans. / Spitzmüller, Zsolt; Hajdú, Márton; Pócsi, I.; Emri, T.

In: Acta Biologica Hungarica, Vol. 66, No. 2, 01.06.2015, p. 242-245.

Research output: Contribution to journalArticle

Spitzmüller, Zsolt ; Hajdú, Márton ; Pócsi, I. ; Emri, T. / Degradation of glutathione in aspergillus nidulans. In: Acta Biologica Hungarica. 2015 ; Vol. 66, No. 2. pp. 242-245.
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